DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_APCC_DBOX_1

Location: 2486:2494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9073

ASA_SCORE: 56.7222

COIL: 0.4841

CONS_SCORE: 0.1979

DSS_SCORE: 0.3937

HELIX: 0.0058

FCONS_SCORE: 0.9737

RIG_SCORE: 0.7765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2486L	TCGA-EO-A3B0	UCEC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	0.7667
p.S2486L	DO219773	UCEC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	0.7667
p.P2478L	TCGA-QC-A7B5	SARC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	0.1111
p.P2478L	DO220239	SARC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1111
p.P2478S	TCGA-QC-A7B5	SARC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	0.1111
p.P2478S	DO220239	SARC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1111
p.R2489G	DO229493	LAML	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	0.6457
p.R2480W	DO231075	LUSC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1667
p.R2480W	SIDM01199	Hepatocellular Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1667
p.R2480W	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1667
p.R2480W	SIDM00489	Oral Cavity Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1667
p.R2480W	SIDM01434	Hepatocellular Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	0.1667
p.R2504L	ACH-001608	Brain Cancer	CCLE	SRLRLLQVT	DEG_APCC_DBOX_1	0.0556
p.V2493M	ACH-002026	Endometrial/Uterine Cancer	CCLE	SRLRLLQVT	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_APCC_DBOX_1	2486:2494	SRLRLLQVT	APC,CDC20,FZR1	0.9073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons