DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_COP1_1

Location: 2620:2628

E3 ligase: COP1

DEGRON score: 0.9381

ASA_SCORE: 75.4

COIL: 0.8943

CONS_SCORE: 0.1952

DSS_SCORE: 0.5111

HELIX: 0.024

FCONS_SCORE: 0.843

RIG_SCORE: 0.6135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2625M	TCGA-EY-A548	UCEC	TCGA	SGSSHVPSV	DEG_COP1_1	0.7208
p.V2625M	DO48173	UCEC	ICGC	SGSSHVPSV	DEG_COP1_1	0.7208
p.V2615I	TCGA-G4-6320	COAD	TCGA	SGSSHVPSV	DEG_COP1_1	0.1944
p.V2615I	DO8159	COAD	ICGC	SGSSHVPSV	DEG_COP1_1	0.1944
p.V2615I	SIDM00535	Chondrosarcoma	GDSC	SGSSHVPSV	DEG_COP1_1	0.1944
p.T2616S	DO7262	CLLE	ICGC	SGSSHVPSV	DEG_COP1_1	0.2222
p.S2627R	DO229036	LICA	ICGC	SGSSHVPSV	DEG_COP1_1	0.7427
p.S2612L	DO34616	PACA	ICGC	SGSSHVPSV	DEG_COP1_1	0.1111
p.V2625A	DO232761	PBCA	ICGC	SGSSHVPSV	DEG_COP1_1	0.6936
p.S2627G	SIDM00217	Colorectal Carcinoma	GDSC	SGSSHVPSV	DEG_COP1_1	0.6993
p.S2627G	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSSHVPSV	DEG_COP1_1	0.6993
p.S2627G	SNU-1040	large_intestine	COSMIC	SGSSHVPSV	DEG_COP1_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_COP1_1	2620:2628	SGSSHVPSV	COP1	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons