DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SCF_FBW7_1

Location: 126:133

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 83.4625

COIL: 0.9204

CONS_SCORE: 0.3541

DSS_SCORE: 0.7808

HELIX: 0.0596

FCONS_SCORE: 0.9903

RIG_SCORE: 0.5521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M117I	TCGA-D3-A2JP	SKCM	TCGA	PTSTPASS	DEG_SCF_FBW7_1	0.0833
p.M117I	DO47407	SKCM	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.0833
p.Q121H	TCGA-EO-A22R	UCEC	TCGA	PTSTPASS	DEG_SCF_FBW7_1	0.1944
p.Q121H	DO42713	UCEC	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.1944
p.R140L	TCGA-L9-A7SV	LUAD	TCGA	PTSTPASS	DEG_SCF_FBW7_1	0.1389
p.R140L	DO49875	LUAD	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.1389
p.R140Q	TCGA-OR-A5KB	ACC	TCGA	PTSTPASS	DEG_SCF_FBW7_1	0.1389
p.S116F	DO233652	GACA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.0556
p.S116F	DO220892	MELA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.0556
p.G134V	DO229008	LICA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.3056
p.A131T	DO50970	LICA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	0.6028
p.S135F	SIDM02041	Colorectal Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.7222
p.S133P	SIDM01954	Colorectal Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.7863
p.A131V	SIDM00377	Other Sarcomas	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.5825
p.A131V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.5825
p.A131V	SIDM00380	Acute Myeloid Leukemia	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.5825
p.A131V	SIDM00168	Head and Neck Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.5825
p.A131V	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTPASS	DEG_SCF_FBW7_1	0.5825
p.R140P	SIDM01174	Cervical Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	0.1389
p.S135P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTSTPASS	DEG_SCF_FBW7_1	0.7222
p.S135P	EN	endometrium	COSMIC	PTSTPASS	DEG_SCF_FBW7_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SCF_FBW7_1	126:133	PTSTPASS	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons