DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: LIG_APCC_ABBA_1

Location: 1038:1043

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 75.8

COIL: 0.8187

CONS_SCORE: 0.4531

DSS_SCORE: 0.341

HELIX: 0.0138

FCONS_SCORE: 1.0054

RIG_SCORE: 0.7863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1053S	TCGA-4A-A93W	KIRP	TCGA	IPPFED	LIG_APCC_ABBA_1	0.0556
p.T1053S	DO219688	KIRP	ICGC	IPPFED	LIG_APCC_ABBA_1	0.0556
p.D1043Y	TCGA-86-8358	LUAD	TCGA	IPPFED	LIG_APCC_ABBA_1	0.7325
p.D1043Y	DO25471	LUAD	ICGC	IPPFED	LIG_APCC_ABBA_1	0.7325
p.V1033L	TCGA-A5-A0G1	UCEC	TCGA	IPPFED	LIG_APCC_ABBA_1	0.1944
p.V1033L	DO42472	UCEC	ICGC	IPPFED	LIG_APCC_ABBA_1	0.1944
p.R1047Q	TCGA-AA-3538	COAD	TCGA	IPPFED	LIG_APCC_ABBA_1	0.2222
p.R1047Q	DO9626	COAD	ICGC	IPPFED	LIG_APCC_ABBA_1	0.2222
p.R1047Q	DO233634	GACA	ICGC	IPPFED	LIG_APCC_ABBA_1	0.2222
p.K1034T	TCGA-BQ-5882	KIRP	TCGA	IPPFED	LIG_APCC_ABBA_1	0.3333
p.K1034T	DO20758	KIRP	ICGC	IPPFED	LIG_APCC_ABBA_1	0.3333
p.G1044D	TCGA-BS-A0TE	UCEC	TCGA	IPPFED	LIG_APCC_ABBA_1	0.3056
p.G1044D	DO43506	UCEC	ICGC	IPPFED	LIG_APCC_ABBA_1	0.3056
p.G1044V	DO229031	LICA	ICGC	IPPFED	LIG_APCC_ABBA_1	0.3056
p.P1040S	DO229456	SKCA	ICGC	IPPFED	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	LIG_APCC_ABBA_1	1038:1043	IPPFED	APC,CDC20,FZR1	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons