DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SCF_TRCP1_1

Location: 1308:1314

E3 ligase: BTRC

DEGRON score: 0.9924

ASA_SCORE: 69.1857

COIL: 0.847

CONS_SCORE: 0.3676

DSS_SCORE: 0.6042

HELIX: 0.0921

FCONS_SCORE: 0.9894

RIG_SCORE: 0.6275

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1303N	TCGA-EE-A2GO	SKCM	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	0.3056
p.K1303N	DO37823	SKCM	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.3056
p.D1308Y	TCGA-FU-A3TQ	CESC	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	0.7325
p.D1308Y	DO44295	CESC	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.7325
p.D1308Y	DO229041	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.7325
p.D1299E	DO229003	COCA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00303	Ovarian Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00589	Oral Cavity Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00492	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00905	Cervical Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00054	Pancreatic Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00294	Small Cell Lung Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00498	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00618	Hepatocellular Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00613	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM00503	Gastric Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01018	Hodgkin's Lymphoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01577	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01470	Acute Myeloid Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01749	Osteosarcoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01320	Pancreatic Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01776	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01378	Ovarian Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299E	SIDM01574	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.D1299G	DO233864	GACA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.G1310V	DO228948	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.7532
p.M1323I	DO229031	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.0833
p.S1324F	DO220891	MELA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.0556
p.S1324F	SIDM00867	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.0556
p.S1324F	ACH-000863	Brain Cancer	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	0.0556
p.S1324F	DBTRG-05MG	central_nervous_system	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.0556
p.S1306C	SIDM02030	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.2778
p.G1310S	SIDM00420	Bladder Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.6993
p.G1310S	SIDM01525	Acute Myeloid Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.6993
p.G1310S	SW1710	urinary_tract	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.6993
p.D1312N	SIDM01679	Small Cell Lung Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SCF_TRCP1_1	1325:1331	DSGIDTT	BTRC	0.9712	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SCF_TRCP1_1	1308:1314	DSGIDTT	BTRC	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGIDTT

Degron related mutations and impact score

Drug responses associated with SIPA1L3 mutations

All proteins holding degron of DSGIDTT