DegronMD

Uniprot ID: O43166

Source protein: Signal-induced proliferation-associated 1-like protein 1

Source gene: SIPA1L1

Class: DEG_SCF_TRCP1_1

Location: 1325:1331

E3 ligase: BTRC

DEGRON score: 0.9712

ASA_SCORE: 67.0571

COIL: 0.8637

CONS_SCORE: 0.4169

DSS_SCORE: 0.549

HELIX: 0.066

FCONS_SCORE: 1.0858

RIG_SCORE: 0.6622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1335H	TCGA-ER-A19N	SKCM	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	0.2222
p.P1335H	DO37452	SKCM	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.2222
p.A1324S	DO229018	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.3056
p.G1334V	DO229026	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.25
p.G1321V	DO229009	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	0.2222
p.N1317D	SIDM01197	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.1111
p.N1317D	SNU-C1	large_intestine	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.1111
p.G1338S	SIDM00258	Neuroblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	0.1389
p.G1338S	NB12	autonomic_ganglia	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.1389
p.V1338M	ACH-000582	Skin Cancer	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	0.1389
p.V1338M	COLO-741	large_intestine	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.1389
p.G1317S	ACH-002279	Neuroblastoma	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	0.1111
p.G1317S	NB12	autonomic_ganglia	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SCF_TRCP1_1	1325:1331	DSGIDTT	BTRC	0.9712	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SCF_TRCP1_1	1308:1314	DSGIDTT	BTRC	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons