DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_APCC_DBOX_1

Location: 1492:1500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9463

ASA_SCORE: 98.9667

COIL: 0.6574

CONS_SCORE: 0.3832

DSS_SCORE: 0.5698

HELIX: 0.2842

FCONS_SCORE: 0.9952

RIG_SCORE: 0.7602

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1506C	TCGA-AX-A063	UCEC	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	0.1667
p.Y1506C	DO42201	UCEC	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.1667
p.A1494S	TCGA-B6-A0IQ	BRCA	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	0.6477
p.A1494S	DO4847	BRCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.6477
p.P1490L	TCGA-E6-A2P8	UCEC	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1490L	DO234459	ESAD	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1490L	DO40924	UCEC	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1502S	TCGA-EE-A2GC	SKCM	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1502S	DO37839	SKCM	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1502L	TCGA-EE-A2GC	SKCM	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.P1502L	DO37839	SKCM	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.2778
p.R1500Q	DO222492	COCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.6218
p.R1500Q	SIDM00213	Thyroid Gland Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.6218
p.R1500Q	ACH-000903	Thyroid Cancer	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	0.6218
p.R1500Q	FTC-133	thyroid	COSMIC	LRASLRDLR	DEG_APCC_DBOX_1	0.6218
p.R1503W	DO50448	ESAD	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM01278	Colorectal Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM01020	Plasma Cell Myeloma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00586	Hepatocellular Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00596	Endometrial Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00410	Other Blood Cancers	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00609	Kidney Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM01019	Acute Myeloid Leukemia	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00239	Kidney Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM00603	Head and Neck Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503W	SIDM01735	Biliary Tract Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.V1486F	DO229025	LICA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.1667
p.N1485T	DO228372	MALY	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.1389
p.S1495F	DO229453	SKCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	0.7982
p.R1503Q	SIDM00202	Ewing's Sarcoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503Q	ACH-001057	Lymphoma	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503Q	ACH-002118	Bone Cancer	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	0.25
p.R1503Q	EW-3	bone	COSMIC	LRASLRDLR	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRASLRDLR

Degron related mutations and impact score

Drug responses associated with SIPA1L3 mutations

All proteins holding degron of LRASLRDLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_APCC_DBOX_1	1492:1500	LRASLRDLR	APC,CDC20,FZR1	0.9463	More...