DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SCF_FBW7_1

Location: 833:840

E3 ligase: FBXW7

DEGRON score: 0.9258

ASA_SCORE: 77.675

COIL: 0.862

CONS_SCORE: 0.4133

DSS_SCORE: 0.3163

HELIX: 0.1094

FCONS_SCORE: 0.8847

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y824D	TCGA-12-0778	GBM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.0833
p.Y824D	DO11411	GBM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.0833
p.T836N	TCGA-22-4595	LUSC	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.7055
p.T836N	DO26641	LUSC	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.7055
p.E823A	TCGA-A8-A09Z	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.0556
p.E823A	DO5521	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.0556
p.P837R	TCGA-D8-A1JP	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.7512
p.P837R	DO5857	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.7512
p.L825F	TCGA-E9-A22E	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.L825F	DO2131	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.S848F	TCGA-EB-A41A	SKCM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.S848F	DO37429	SKCM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.P837H	TCGA-ER-A2NE	SKCM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.7694
p.P837H	DO48663	SKCM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.7694
p.L828M	TCGA-IB-7651	PAAD	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	0.1944
p.L828M	DO46657	PAAD	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.1944
p.G842S	DO220824	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.2778
p.D827Y	DO229022	LICA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	0.1667
p.K826E	SIDM00596	Endometrial Carcinoma	GDSC	VSNTPIDS	DEG_SCF_FBW7_1	0.25
p.K826E	ACH-000941	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	0.25
p.K826E	ACH-000954	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	0.25
p.K826E	ACH-001517	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	0.25
p.K826E	HEC-1	endometrium	COSMIC	VSNTPIDS	DEG_SCF_FBW7_1	0.25
p.L825V	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.L825V	ACH-000861	Lung Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.L825V	HOP-62	lung	COSMIC	VSNTPIDS	DEG_SCF_FBW7_1	0.1111
p.N831D	ACH-001418	Ovarian Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SCF_FBW7_1	833:840	VSNTPIDS	FBXW7	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSNTPIDS

Degron related mutations and impact score

Drug responses associated with SIPA1L3 mutations

All proteins holding degron of VSNTPIDS