DegronMD

Uniprot ID: O15457

Source protein: MutS protein homolog 4

Source gene: MSH4

Class: DEG_SCF_FBW7_1

Location: 118:124

E3 ligase: FBXW7

DEGRON score: 0.9997

ASA_SCORE: 78.2143

COIL: 0.8324

CONS_SCORE: 0.2909

DSS_SCORE: 0.6275

HELIX: 0.1056

FCONS_SCORE: 1.0709

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R129G	TCGA-13-0764	OV	TCGA	LKTPLST	DEG_SCF_FBW7_1	0.1944
p.R129G	DO30930	OV	ICGC	LKTPLST	DEG_SCF_FBW7_1	0.1944
p.D111Y	TCGA-BS-A0UF	UCEC	TCGA	LKTPLST	DEG_SCF_FBW7_1	0.1389
p.D111Y	DO41488	UCEC	ICGC	LKTPLST	DEG_SCF_FBW7_1	0.1389
p.D111N	TCGA-IZ-8196	KIRP	TCGA	LKTPLST	DEG_SCF_FBW7_1	0.1389
p.D111N	DO44461	KIRP	ICGC	LKTPLST	DEG_SCF_FBW7_1	0.1389
p.A109T	DO222769	COCA	ICGC	LKTPLST	DEG_SCF_FBW7_1	0.0833
p.P121L	DO218898	SKCA	ICGC	LKTPLST	DEG_SCF_FBW7_1	0.7582
p.P127L	SIDM00545	Melanoma	GDSC	LKTPLST	DEG_SCF_FBW7_1	0.25
p.P127L	ACH-000987	Skin Cancer	CCLE	LKTPLST	DEG_SCF_FBW7_1	0.25
p.P127L	Mewo	skin	COSMIC	LKTPLST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15457	MutS protein homolog 4	DEG_SCF_FBW7_1	118:124	LKTPLST	FBXW7	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons