DegronMD - Q5VYM1(C9orf131)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G533E	TCGA-2W-A8YY	CESC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.0556
p.L507F	TCGA-AA-A010	COAD	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.0833
p.P513L	TCGA-AP-A1DK	UCEC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.25
p.P696L	TCGA-BA-4077	HNSC	TCGA	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.6471
p.W508C	TCGA-BK-A13B	UCEC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1111
p.L695V	TCGA-CV-6441	HNSC	TCGA	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.5654
p.M525I	TCGA-D3-A3ML	SKCM	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.2778
p.M525I	SIDM01175	Other Sarcomas	GDSC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.2778
p.M525I	ACH-002309	Sarcoma	CCLE	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.2778
p.E526A	TCGA-DU-6392	LGG	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.25
p.G959E	TCGA-IH-A3EA	SKCM	TCGA	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation rewiring degron network	0.2778
p.E697Q	TCGA-XF-A9T5	BLCA	TCGA	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.6744
p.K843N	DO51881	BLCA	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation altering degron motif	0.6918
p.P957A	DO225305	BRCA	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation rewiring degron network	0.2222
p.Q853L	DO225336	BRCA	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0833
p.L960F	DO52458	COCA	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation blocking phosphorylation signal	0.75
p.G854W	DO233898	GACA	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0556
p.C706R	DO13456	GBM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.0833
p.P967T	DO50006	HNSC	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation altering degron motif	0.7031
p.P967T	DO26566	LUSC	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation altering degron motif	0.7031
p.S852F	DO228213	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1111
p.A832S	DO228985	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1111
p.R695H	DO49657	LIHC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.8244
p.R695H	DO41331	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.8244
p.R695S	DO25396	LUAD	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.7427
p.P957H	DO23738	LUAD	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation rewiring degron network	0.2222
p.S848R	DO23558	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2222
p.S848R	DO27088	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2222
p.S848R	DO42985	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2222
p.G531E	DO26477	LUSC	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.1111
p.R838S	DO27823	MALY	ICGC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2778
p.T705K	DO51065	PRAD	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.1111
p.P517H	DO47112	RECA	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7694
p.V527F	DO220303	SARC	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation rewiring degron network	0.2222
p.P517L	DO229453	SKCA	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.7582
p.G703R	DO37631	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.1667
p.G703E	DO37886	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.1667
p.K702N	DO37823	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.1944
p.G966S	DO37447	SKCM	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	961:969	Mutation altering degron motif	0.6993
p.L700I	DO52412	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation rewiring degron network	0.25
p.R695C	DO42633	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	691:697	Mutation altering degron motif	0.8301
p.V516I	SIDM00217	Colorectal Carcinoma	GDSC	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.5965
p.V516I	ACH-000999	Colon/Colorectal Cancer	CCLE	VHSTPPTT	DEG_SCF_FBW7_1	516:523	Mutation altering degron motif	0.5965
p.R852C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1111
p.R852C	ACH-000937	Leukemia	CCLE	PHSSS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C9orf131

UniProt ID: Q5VYM1

Entrez ID: 138724

Protein name: Uncharacterized protein C9orf131

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C9orf131 in