DegronMD

Uniprot ID: Q5VYM1

Source protein: Uncharacterized protein C9orf131

Source gene: C9orf131

Class: DEG_SCF_FBW7_2

Location: 691:697

E3 ligase: FBXW7

DEGRON score: 0.9486

ASA_SCORE: 89.4286

COIL: 0.9581

CONS_SCORE: 0.6097

DSS_SCORE: 0.525

HELIX: 0.0177

FCONS_SCORE: 0.8396

RIG_SCORE: 0.6194

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P696L	TCGA-BA-4077	HNSC	TCGA	LSTPLPE	DEG_SCF_FBW7_2	0.6471
p.L695V	TCGA-CV-6441	HNSC	TCGA	LSTPLPE	DEG_SCF_FBW7_2	0.5654
p.E697Q	TCGA-XF-A9T5	BLCA	TCGA	LSTPLPE	DEG_SCF_FBW7_2	0.6744
p.C706R	DO13456	GBM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.0833
p.R695H	DO49657	LIHC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.8244
p.R695H	DO41331	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.8244
p.R695S	DO25396	LUAD	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.7427
p.T705K	DO51065	PRAD	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.1111
p.G703R	DO37631	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.1667
p.G703E	DO37886	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.1667
p.K702N	DO37823	SKCM	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.1944
p.L700I	DO52412	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.25
p.R695C	DO42633	UCEC	ICGC	LSTPLPE	DEG_SCF_FBW7_2	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYM1	Uncharacterized protein C9orf131	DEG_SCF_FBW7_2	691:697	LSTPLPE	FBXW7	0.9486	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons