DegronMD

Uniprot ID: Q5VYM1

Source protein: Uncharacterized protein C9orf131

Source gene: C9orf131

Class: DEG_SCF_FBW7_1

Location: 516:523

E3 ligase: FBXW7

DEGRON score: 0.9357

ASA_SCORE: 93.8625

COIL: 0.9615

CONS_SCORE: 0.5144

DSS_SCORE: 0.6856

HELIX: 0.0161

FCONS_SCORE: 0.8258

RIG_SCORE: 0.6186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G533E	TCGA-2W-A8YY	CESC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.0556
p.L507F	TCGA-AA-A010	COAD	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.0833
p.P513L	TCGA-AP-A1DK	UCEC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.25
p.W508C	TCGA-BK-A13B	UCEC	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.1111
p.M525I	TCGA-D3-A3ML	SKCM	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.2778
p.M525I	SIDM01175	Other Sarcomas	GDSC	VHSTPPTT	DEG_SCF_FBW7_1	0.2778
p.M525I	ACH-002309	Sarcoma	CCLE	VHSTPPTT	DEG_SCF_FBW7_1	0.2778
p.E526A	TCGA-DU-6392	LGG	TCGA	VHSTPPTT	DEG_SCF_FBW7_1	0.25
p.G531E	DO26477	LUSC	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	0.1111
p.P517H	DO47112	RECA	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	0.7694
p.V527F	DO220303	SARC	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	0.2222
p.P517L	DO229453	SKCA	ICGC	VHSTPPTT	DEG_SCF_FBW7_1	0.7582
p.V516I	SIDM00217	Colorectal Carcinoma	GDSC	VHSTPPTT	DEG_SCF_FBW7_1	0.5965
p.V516I	ACH-000999	Colon/Colorectal Cancer	CCLE	VHSTPPTT	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYM1	Uncharacterized protein C9orf131	DEG_SCF_FBW7_1	516:523	VHSTPPTT	FBXW7	0.9357	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons