DegronMD

Uniprot ID: Q5VYM1

Source protein: Uncharacterized protein C9orf131

Source gene: C9orf131

Class: DEG_APCC_DBOX_1

Location: 961:969

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9565

ASA_SCORE: 87.1333

COIL: 0.8683

CONS_SCORE: 0.7988

DSS_SCORE: 0.7248

HELIX: 0.073

FCONS_SCORE: 1.116

RIG_SCORE: 0.6562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G959E	TCGA-IH-A3EA	SKCM	TCGA	ARLGLSTVT	DEG_APCC_DBOX_1	0.2778
p.P957A	DO225305	BRCA	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.2222
p.L960F	DO52458	COCA	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.75
p.P967T	DO50006	HNSC	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.7031
p.P967T	DO26566	LUSC	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.7031
p.P957H	DO23738	LUAD	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.2222
p.G966S	DO37447	SKCM	ICGC	ARLGLSTVT	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYM1	Uncharacterized protein C9orf131	DEG_APCC_DBOX_1	961:969	ARLGLSTVT	APC,CDC20,FZR1	0.9565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons