DegronMD - O75747(PIK3C2G)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V27E	TCGA-24-1603	OV	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.V27E	DO31010	OV	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.25
p.L25I	TCGA-AA-3510	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.L25I	TCGA-BK-A6W3	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.L25I	DO7783	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.L25I	DO50076	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.I43L	TCGA-BK-A6W3	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.I43L	DO50076	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.N28K	TCGA-CJ-6031	KIRC	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2778
p.N28K	DO16668	KIRC	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2778
p.E55K	TCGA-D3-A3C8	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.E55K	TCGA-ER-A19D	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.E55K	DO234184	ESAD	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.E55K	DO37750	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.E55K	DO47636	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.K153E	TCGA-DD-AACI	LIHC	TCGA	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.591
p.K153E	DO52205	LIHC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.591
p.E163K	TCGA-EE-A29D	SKCM	TCGA	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.1389
p.E163K	DO38123	SKCM	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.1389
p.D72N	TCGA-FS-A1ZZ	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.D72N	DO37412	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2222
p.S77A	TCGA-NH-A50V	COAD	TCGA	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.0833
p.S77A	DO44094	COAD	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.0833
p.Q35E	TCGA-VS-A959	CESC	TCGA	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.3056
p.Q35E	DO51640	CESC	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.3056
p.P146L	DO222990	BTCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO227999	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO229010	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO229013	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO234285	ESAD	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO230550	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.P146L	DO52365	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.7582
p.V44I	DO223528	CLLE	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0556
p.P30S	DO233624	GACA	ICGC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.P30S	SIDM00282	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.P30S	ACH-000998	Colon/Colorectal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.P30S	CW-2	large intestine	COSMIC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation altering degron motif	0.6752
p.G135D	DO233766	GACA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.0833
p.D138Y	DO229008	LICA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.1667
p.H165R	DO230927	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.0833
p.H165R	DO224570	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.0833
p.N162H	DO228875	MALY	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.1667
p.S147L	DO222402	MELA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.6556
p.P52L	DO229453	SKCA	ICGC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.1389
p.S150R	SIDM02064	Colorectal Carcinoma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation altering degron motif	0.6316
p.S142N	SIDM00993	Plasma Cell Myeloma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.2778
p.S142N	ACH-000838	Myeloma	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.2778
p.S142N	AMO-1	haematopoietic and lymphoid tissue	COSMIC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.2778
p.P69S	SIDM00935	Other Solid Cancers	GDSC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.3056
p.P69S	SIDM01110	Hepatocellular Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.3056
p.H134N	SIDM00255	Neuroblastoma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.0556
p.H134N	ACH-002282	Neuroblastoma	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.0556
p.I58T	SIDM00193	Colorectal Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.3056
p.I58T	ACH-000991	Colon/Colorectal Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.3056
p.I58T	SNU-81	large intestine	COSMIC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.3056
p.G39S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.G39S	ACH-000435	Endometrial/Uterine Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.G39S	ACH-000823	Esophageal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.G39S	KYSE-140	oesophagus	COSMIC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1944
p.D41E	SIDM00282	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.D41E	ACH-000998	Colon/Colorectal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.D41E	CW-2	large intestine	COSMIC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.G75W	SIDM00282	Colorectal Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.1389
p.G75W	ACH-000998	Colon/Colorectal Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.1389
p.G75W	CW-2	large intestine	COSMIC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.1389
p.F24L	SIDM01018	Hodgkin's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1667
p.F24L	ACH-000815	Lymphoma	CCLE	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1667
p.F24L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1667
p.K70R	SIDM01412	Oral Cavity Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2778
p.K70R	ACH-000762	Head and Neck Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	59:68	Mutation rewiring degron network	0.2778
p.A136V	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	144:156	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3C2G

UniProt ID: O75747

Entrez ID: 5288

Protein name: Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.137) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3C2G in