DegronMD

Uniprot ID: O75747

Source protein: Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Source gene: PIK3C2G

Class: DEG_COP1_1

Location: 59:68

E3 ligase: COP1

DEGRON score: 0.9933

ASA_SCORE: 64.98

COIL: 0.7929

CONS_SCORE: 0.3995

DSS_SCORE: 0.4226

HELIX: 0.1362

FCONS_SCORE: 1.1553

RIG_SCORE: 0.7938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E55K	TCGA-D3-A3C8	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	0.2222
p.E55K	TCGA-ER-A19D	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	0.2222
p.E55K	DO234184	ESAD	ICGC	DENTFFVPTA	DEG_COP1_1	0.2222
p.E55K	DO37750	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	0.2222
p.E55K	DO47636	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	0.2222
p.D72N	TCGA-FS-A1ZZ	SKCM	TCGA	DENTFFVPTA	DEG_COP1_1	0.2222
p.D72N	DO37412	SKCM	ICGC	DENTFFVPTA	DEG_COP1_1	0.2222
p.S77A	TCGA-NH-A50V	COAD	TCGA	DENTFFVPTA	DEG_COP1_1	0.0833
p.S77A	DO44094	COAD	ICGC	DENTFFVPTA	DEG_COP1_1	0.0833
p.P52L	DO229453	SKCA	ICGC	DENTFFVPTA	DEG_COP1_1	0.1389
p.P69S	SIDM00935	Other Solid Cancers	GDSC	DENTFFVPTA	DEG_COP1_1	0.3056
p.P69S	SIDM01110	Hepatocellular Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	0.3056
p.I58T	SIDM00193	Colorectal Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	0.3056
p.I58T	ACH-000991	Colon/Colorectal Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	0.3056
p.I58T	SNU-81	large_intestine	COSMIC	DENTFFVPTA	DEG_COP1_1	0.3056
p.G75W	SIDM00282	Colorectal Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	0.1389
p.G75W	ACH-000998	Colon/Colorectal Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	0.1389
p.G75W	CW-2	large_intestine	COSMIC	DENTFFVPTA	DEG_COP1_1	0.1389
p.K70R	SIDM01412	Oral Cavity Carcinoma	GDSC	DENTFFVPTA	DEG_COP1_1	0.2778
p.K70R	ACH-000762	Head and Neck Cancer	CCLE	DENTFFVPTA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_COP1_1	59:68	DENTFFVPTA	COP1	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons