DegronMD

Uniprot ID: O75747

Source protein: Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Source gene: PIK3C2G

Class: DEG_ODPH_VHL_1

Location: 144:156

E3 ligase: VHL

DEGRON score: 0.9736

ASA_SCORE: 74.1385

COIL: 0.7632

CONS_SCORE: 0.4151

DSS_SCORE: 0.3501

HELIX: 0.1674

FCONS_SCORE: 1.2143

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K153E	TCGA-DD-AACI	LIHC	TCGA	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.591
p.K153E	DO52205	LIHC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.591
p.E163K	TCGA-EE-A29D	SKCM	TCGA	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.1389
p.E163K	DO38123	SKCM	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.1389
p.P146L	DO222990	BTCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO227999	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO229010	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO229013	COCA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO234285	ESAD	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO230550	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.P146L	DO52365	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.7582
p.G135D	DO233766	GACA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.0833
p.D138Y	DO229008	LICA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.1667
p.H165R	DO230927	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.0833
p.H165R	DO224570	LUSC	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.0833
p.N162H	DO228875	MALY	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.1667
p.S147L	DO222402	MELA	ICGC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.6556
p.S150R	SIDM02064	Colorectal Carcinoma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.6316
p.S142N	SIDM00993	Plasma Cell Myeloma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.2778
p.S142N	ACH-000838	Myeloma	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.2778
p.S142N	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.2778
p.H134N	SIDM00255	Neuroblastoma	GDSC	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.0556
p.H134N	ACH-002282	Neuroblastoma	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.0556
p.A136V	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPSFTSLDKINL	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_ODPH_VHL_1	144:156	LAPSFTSLDKINL	VHL	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSFTSLDKINL

Degron related mutations and impact score

Drug responses associated with PIK3C2G mutations

All proteins holding degron of LAPSFTSLDKINL