DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 1060:1066

E3 ligase: BTRC

DEGRON score: 0.9879

ASA_SCORE: 100.8429

COIL: 0.9473

CONS_SCORE: 0.1923

DSS_SCORE: 0.7494

HELIX: 0.0364

FCONS_SCORE: 0.9919

RIG_SCORE: 0.5403

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1063Q	TCGA-75-5126	LUAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.647
p.H1063Q	DO23711	LUAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.647
p.W1064R	TCGA-BR-6802	STAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.7523
p.W1064R	TCGA-WS-AB45	COAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.7523
p.W1064R	DO51734	COAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.7523
p.W1064R	DO228967	LICA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.7523
p.W1064R	DO38332	STAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.7523
p.G1065R	TCGA-D9-A3Z1	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.6457
p.G1065R	DO38105	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.6457
p.R1051C	TCGA-EO-A22R	UCEC	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	DO222371	BTCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	DO227976	COCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	DO233765	GACA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	DO42713	UCEC	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.R1051C	ACH-001127	Leukemia	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	0.0833
p.D1073N	TCGA-ER-A42K	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.1389
p.D1073N	DO51252	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.1389
p.S1055L	TCGA-FR-A728	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.6389
p.S1055L	DO48550	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.6389
p.A1057E	TCGA-L5-A8NG	ESCA	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.25
p.S1056F	TCGA-QB-A6FS	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.2222
p.S1056F	DO48654	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.2222
p.G1062R	TCGA-VQ-A8P8	STAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	0.7568
p.G1062R	DO51764	STAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.7568
p.G1062R	ACH-002664	Colon/Colorectal Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	0.7568
p.A1054S	DO52488	COCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.1667
p.S1066T	DO228848	LICA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.6005
p.S1056C	DO220864	MELA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.2222
p.S1066F	DO232224	PBCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	0.7982
p.R1052G	SIDM00353	Other Sarcomas	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM01040	Ovarian Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00569	Osteosarcoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00057	Neuroblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00552	Rhabdomyosarcoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00457	Plasma Cell Myeloma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM01196	Hepatocellular Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM01210	Glioblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00543	Melanoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00363	Acute Myeloid Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00026	Other Solid Cancers	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00170	Head and Neck Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.R1052G	SIDM00162	Biliary Tract Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1111
p.G1062E	SIDM00545	Melanoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.7199
p.G1062E	SIDM01412	Oral Cavity Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.7199
p.G1062E	ACH-000762	Head and Neck Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	0.7199
p.G1062E	ACH-000987	Skin Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	0.7199
p.G1062E	Mewo	skin	COSMIC	DSGHWGS	DEG_SCF_TRCP1_1	0.7199
p.A1071V	SIDM00157	Neuroblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	0.1944
p.A1071V	ACH-002261	Neuroblastoma	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	0.1944
p.A1071V	KP-N-YS	autonomic_ganglia	COSMIC	DSGHWGS	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHWGS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of DSGHWGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SCF_TRCP1_1	1060:1066	DSGHWGS	BTRC	0.9879	More...