DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_APCC_KENBOX_2

Location: 118:122

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7527

ASA_SCORE: 153.8

COIL: 0.9336

CONS_SCORE: 0.2891

DSS_SCORE: 0.806

HELIX: 0.0704

FCONS_SCORE: 0.8224

RIG_SCORE: 0.5859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E116K	TCGA-3N-A9WD	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	TCGA-EE-A3AA	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	TCGA-GN-A268	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	DO222632	MELA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	DO37571	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	DO37477	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E116K	DO51235	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E129D	TCGA-B5-A121	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1389
p.E129D	DO43394	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1389
p.K109E	TCGA-CF-A1HS	BLCA	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1944
p.K109E	DO486	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.R130T	TCGA-CN-4723	HNSC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1111
p.R130T	DO14830	HNSC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1111
p.R122K	TCGA-D3-A8GC	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.6126
p.R122K	TCGA-GN-A4U5	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.6126
p.R122K	DO50281	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6126
p.R122K	DO51257	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6126
p.S127G	TCGA-D7-A6F0	STAD	TCGA	NKENR	DEG_APCC_KENBOX_2	0.6389
p.S127G	DO50120	STAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6389
p.R124I	TCGA-GS-A9TZ	DLBC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.2778
p.R124I	DO219918	DLBC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.R124I	DO51955	PRAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E111K	TCGA-UY-A9PF	BLCA	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1389
p.E111K	DO219044	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1389
p.E120K	TCGA-VS-A9UL	CESC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.7022
p.E120K	DO51643	CESC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.7022
p.E120K	DO222710	MELA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.7022
p.S127N	DO45096	LIRI	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6389
p.S127R	FTC-133	thyroid	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_APCC_KENBOX_2	108:112	NKENR	APC,CDC20,FZR1	0.7627	More...
P20930	Filaggrin	DEG_APCC_KENBOX_2	118:122	NKENR	APC,CDC20,FZR1	0.7527	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	116:120	NKENR	APC,CDC20,FZR1	0.9218	More...
Q6PKC3	Thioredoxin domain-containing protein 11	DEG_APCC_KENBOX_2	979:983	NKENR	APC,CDC20,FZR1	0.9541	More...
Q9H169	Stathmin-4	DEG_APCC_KENBOX_2	152:156	NKENR	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENR

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of NKENR