DegronMD

Uniprot ID: Q6PKC3

Source protein: Thioredoxin domain-containing protein 11

Source gene: TXNDC11

Class: DEG_APCC_KENBOX_2

Location: 979:983

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9541

ASA_SCORE: 126.9

COIL: 0.8892

CONS_SCORE: 0.3475

DSS_SCORE: 0.9273

HELIX: 0.0918

FCONS_SCORE: 1.0758

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E977Q	DO590	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E981D	DO43306	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6758
p.V970I	SIDM01588	Endometrial Carcinoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.V970I	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENR	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_APCC_KENBOX_2	108:112	NKENR	APC,CDC20,FZR1	0.7627	More...
P20930	Filaggrin	DEG_APCC_KENBOX_2	118:122	NKENR	APC,CDC20,FZR1	0.7527	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	116:120	NKENR	APC,CDC20,FZR1	0.9218	More...
Q6PKC3	Thioredoxin domain-containing protein 11	DEG_APCC_KENBOX_2	979:983	NKENR	APC,CDC20,FZR1	0.9541	More...
Q9H169	Stathmin-4	DEG_APCC_KENBOX_2	152:156	NKENR	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons