DegronMD

Uniprot ID: P16949

Source protein: Stathmin

Source gene: STMN1

Class: DEG_APCC_KENBOX_2

Location: 108:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7627

ASA_SCORE: 111.7

COIL: 0.0688

CONS_SCORE: 0.6504

DSS_SCORE: 0.627

HELIX: 0.9362

FCONS_SCORE: 1.0589

RIG_SCORE: 0.6839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R122P	TCGA-17-Z000	LUAD	TCGA	NKENR	DEG_APCC_KENBOX_2	0.0556
p.R112Q	TCGA-A5-A0G2	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.6218
p.R112Q	DO41235	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6218
p.E110K	TCGA-LN-A4A9	ESCA	TCGA	NKENR	DEG_APCC_KENBOX_2	0.7022
p.H103N	DO229035	LICA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_APCC_KENBOX_2	108:112	NKENR	APC,CDC20,FZR1	0.7627	More...
P20930	Filaggrin	DEG_APCC_KENBOX_2	118:122	NKENR	APC,CDC20,FZR1	0.7527	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	116:120	NKENR	APC,CDC20,FZR1	0.9218	More...
Q6PKC3	Thioredoxin domain-containing protein 11	DEG_APCC_KENBOX_2	979:983	NKENR	APC,CDC20,FZR1	0.9541	More...
Q9H169	Stathmin-4	DEG_APCC_KENBOX_2	152:156	NKENR	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons