DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_APCC_KENBOX_2

Location: 116:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9218

ASA_SCORE: 119.12

COIL: 0.428

CONS_SCORE: 0.6618

DSS_SCORE: 0.613

HELIX: 0.5612

FCONS_SCORE: 1.2627

RIG_SCORE: 0.6531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K107N	TCGA-EO-A3B0	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1944
p.K107N	DO219773	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.K107N	SIDM00118	Colorectal Carcinoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.K107N	ACH-001081	Colon/Colorectal Cancer	CCLE	NKENR	DEG_APCC_KENBOX_2	0.1944
p.K107N	HCC2998	large_intestine	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.N108I	TCGA-ER-A194	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1111
p.N108I	DO47646	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1111
p.E121K	DO229364	BTCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.3056
p.N119S	DO227987	COCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.7069
p.Q127K	DO228978	LICA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1389
p.F108V	DO24441	LUAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1111
p.A123T	DO229257	THCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.3611
p.S129C	SIDM00216	Colorectal Carcinoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.S129C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.S129C	SIDM01446	Glioblastoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.S129C	SNU-175	large_intestine	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.R130H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	NKENR	DEG_APCC_KENBOX_2	0.0556
p.R130H	ACH-000795	Leukemia	CCLE	NKENR	DEG_APCC_KENBOX_2	0.0556
p.R130H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.0556
p.S129R	ACH-001796	Liposarcoma	CCLE	NKENR	DEG_APCC_KENBOX_2	0.0833
p.F108C	ES-2	ovary	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_APCC_KENBOX_2	108:112	NKENR	APC,CDC20,FZR1	0.7627	More...
P20930	Filaggrin	DEG_APCC_KENBOX_2	118:122	NKENR	APC,CDC20,FZR1	0.7527	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	116:120	NKENR	APC,CDC20,FZR1	0.9218	More...
Q6PKC3	Thioredoxin domain-containing protein 11	DEG_APCC_KENBOX_2	979:983	NKENR	APC,CDC20,FZR1	0.9541	More...
Q9H169	Stathmin-4	DEG_APCC_KENBOX_2	152:156	NKENR	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons