DegronMD

Uniprot ID: Q9H169

Source protein: Stathmin-4

Source gene: STMN4

Class: DEG_APCC_KENBOX_2

Location: 152:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9251

ASA_SCORE: 110.78

COIL: 0.1096

CONS_SCORE: 0.6899

DSS_SCORE: 0.5632

HELIX: 0.896

FCONS_SCORE: 1.173

RIG_SCORE: 0.658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E160K	TCGA-EB-A431	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	0.2222
p.N161D	TCGA-EY-A1GQ	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	0.1944
p.N161D	DO43090	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.E154K	DO223588	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.7022
p.R166W	DO234429	ESAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.0556
p.R166W	DO233623	GACA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.0556
p.R166W	DO47981	STAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.0556
p.A161D	DO233154	GACA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.A161D	DO38483	STAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.E150K	DO13845	GBM	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.E150K	DO222837	MELA	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.A158T	DO228665	PRAD	ICGC	NKENR	DEG_APCC_KENBOX_2	0.2778
p.A161T	DO43306	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.1944
p.E154D	DO43154	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	0.6758
p.R151K	SIDM00351	Oral Cavity Carcinoma	GDSC	NKENR	DEG_APCC_KENBOX_2	0.3056
p.R151K	SAS	upper_aerodigestive_tract	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.3056
p.E143K	ACH-000835	Sarcoma	CCLE	NKENR	DEG_APCC_KENBOX_2	0.0833
p.E143K	GCT	soft_tissue	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.0833
p.A146T	ACH-000978	Endometrial/Uterine Cancer	CCLE	NKENR	DEG_APCC_KENBOX_2	0.1667
p.A146T	EN	endometrium	COSMIC	NKENR	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_APCC_KENBOX_2	108:112	NKENR	APC,CDC20,FZR1	0.7627	More...
P20930	Filaggrin	DEG_APCC_KENBOX_2	118:122	NKENR	APC,CDC20,FZR1	0.7527	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	116:120	NKENR	APC,CDC20,FZR1	0.9218	More...
Q6PKC3	Thioredoxin domain-containing protein 11	DEG_APCC_KENBOX_2	979:983	NKENR	APC,CDC20,FZR1	0.9541	More...
Q9H169	Stathmin-4	DEG_APCC_KENBOX_2	152:156	NKENR	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons