DegronMD - P16949(STMN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S28P	TCGA-06-5416	GBM	TCGA	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.7863
p.S28P	DO10880	GBM	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.7863
p.R122P	TCGA-17-Z000	LUAD	TCGA	NKENR	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.0556
p.R112Q	TCGA-A5-A0G2	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.6218
p.R112Q	DO41235	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.6218
p.S31Y	TCGA-AA-A010	COAD	TCGA	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.712
p.P39S	TCGA-D3-A2JF	SKCM	TCGA	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.2222
p.P39S	DO38153	SKCM	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.2222
p.K29I	TCGA-DD-AADS	LIHC	TCGA	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.642
p.K29I	DO52247	LIHC	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.642
p.E110K	TCGA-LN-A4A9	ESCA	TCGA	NKENR	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.7022
p.L24F	DO48362	BLCA	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.3056
p.H103N	DO229035	LICA	ICGC	NKENR	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1944
p.E30K	DO222395	MELA	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.591
p.E30Q	DO46402	OV	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.5633
p.S31P	DO35611	PBCA	ICGC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation altering degron motif	0.6752
p.P36T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.3056
p.P36T	ACH-001127	Leukemia	CCLE	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.3056
p.P36T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SPRSKESVPEF	DEG_COP1_1	25:35	Mutation rewiring degron network	0.3056

Kaplan plot for STMN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STMN1

UniProt ID: P16949

Entrez ID: 3925

Protein name: Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STMN1 in