DegronMD

Uniprot ID: P16949

Source protein: Stathmin

Source gene: STMN1

Class: DEG_COP1_1

Location: 25:35

E3 ligase: COP1

DEGRON score: 0.983

ASA_SCORE: 89.7545

COIL: 0.8652

CONS_SCORE: 0.5146

DSS_SCORE: 0.4963

HELIX: 0.0138

FCONS_SCORE: 0.754

RIG_SCORE: 0.6519

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S28P	TCGA-06-5416	GBM	TCGA	SPRSKESVPEF	DEG_COP1_1	0.7863
p.S28P	DO10880	GBM	ICGC	SPRSKESVPEF	DEG_COP1_1	0.7863
p.S31Y	TCGA-AA-A010	COAD	TCGA	SPRSKESVPEF	DEG_COP1_1	0.712
p.S31P	DO35611	PBCA	ICGC	SPRSKESVPEF	DEG_COP1_1	0.6752
p.K29I	TCGA-DD-AADS	LIHC	TCGA	SPRSKESVPEF	DEG_COP1_1	0.642
p.K29I	DO52247	LIHC	ICGC	SPRSKESVPEF	DEG_COP1_1	0.642
p.E30K	DO222395	MELA	ICGC	SPRSKESVPEF	DEG_COP1_1	0.591
p.E30Q	DO46402	OV	ICGC	SPRSKESVPEF	DEG_COP1_1	0.5633
p.L24F	DO48362	BLCA	ICGC	SPRSKESVPEF	DEG_COP1_1	0.3056
p.P36T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPRSKESVPEF	DEG_COP1_1	0.3056
p.P36T	ACH-001127	Leukemia	CCLE	SPRSKESVPEF	DEG_COP1_1	0.3056
p.P36T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPRSKESVPEF	DEG_COP1_1	0.3056
p.P39S	TCGA-D3-A2JF	SKCM	TCGA	SPRSKESVPEF	DEG_COP1_1	0.2222
p.P39S	DO38153	SKCM	ICGC	SPRSKESVPEF	DEG_COP1_1	0.2222

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16949	Stathmin	DEG_COP1_1	25:35	SPRSKESVPEF	COP1	0.983	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons