DegronMD

Uniprot ID: O00515

Source protein: Ladinin-1

Source gene: LAD1

Class: DEG_APCC_DBOX_1

Location: 118:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9889

ASA_SCORE: 99.2667

COIL: 0.9219

CONS_SCORE: 0.3911

DSS_SCORE: 0.5889

HELIX: 0.042

FCONS_SCORE: 0.8408

RIG_SCORE: 0.6237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S123R	TCGA-06-1800	GBM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.7427
p.Q129H	TCGA-A5-A0G2	UCEC	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.25
p.A127T	TCGA-B5-A5OC	UCEC	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.3056
p.E111K	TCGA-D9-A6EA	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.1389
p.P108S	TCGA-EB-A3XB	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.0556
p.E117D	TCGA-EE-A2M5	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	0.3056
p.V115G	DO48392	BLCA	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.25
p.A119E	DO228948	LICA	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.7701
p.R113P	DO218921	LUAD	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.1944
p.R109Q	DO37679	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.0833
p.P122S	DO37856	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.6752
p.E131D	DO37425	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.1944
p.E125K	DO50290	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.7022
p.R119G	ACH-000588	Myeloma	CCLE	GRNSLSPVQ	DEG_APCC_DBOX_1	0.7568
p.V116G	SNU-407	large_intestine	COSMIC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.2778
p.R109W	NCI-H2347	lung	COSMIC	GRNSLSPVQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00515	Ladinin-1	DEG_APCC_DBOX_1	118:126	GRNSLSPVQ	APC,CDC20,FZR1	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons