DegronMD

Uniprot ID: Q9H0C8

Source protein: Integrin-linked kinase-associated serine/threonine phosphatase 2C

Source gene: ILKAP

Class: DEG_SCF_TRCP1_1

Location: 58:64

E3 ligase: BTRC

DEGRON score: 0.9425

ASA_SCORE: 75.3

COIL: 0.7664

CONS_SCORE: 0.3329

DSS_SCORE: 0.6182

HELIX: 0.1886

FCONS_SCORE: 1.0071

RIG_SCORE: 0.6091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F48L	TCGA-24-1413	OV	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.0556
p.F48L	DO31310	OV	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.0556
p.S61Y	TCGA-AX-A0J0	UCEC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.S61Y	TCGA-BS-A0UV	UCEC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.S61Y	TCGA-DU-6392	LGG	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.S61Y	DO22237	LGG	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.S61Y	DO41133	UCEC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.S61Y	DO42793	UCEC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6009
p.D58N	TCGA-B2-4098	KIRC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.6932
p.D58N	DO19573	KIRC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6932
p.G74E	TCGA-DX-A8BP	SARC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.0556
p.G74E	DO220056	SARC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.0556
p.A54T	TCGA-VQ-A8P2	STAD	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54T	DO51761	STAD	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54T	SIDM01018	Hodgkin's Lymphoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54T	ACH-000815	Lymphoma	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54T	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.G57D	DO233767	GACA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.3056
p.P52Q	DO229018	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.1667
p.A63D	DO229027	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6682
p.A63D	DO229031	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	0.6682
p.D58Y	SIDM00120	Prostate Carcinoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	0.7325
p.D58Y	ACH-000979	Prostate Cancer	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	0.7325
p.D58Y	DU-145	prostate	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	0.7325
p.A54V	SIDM00901	Endometrial Carcinoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54V	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	0.2222
p.A54V	AN3-CA	endometrium	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	DEG_SCF_TRCP1_1	58:64	DSGSLAT	BTRC	0.9425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSLAT

Degron related mutations and impact score

Drug responses associated with ILKAP mutations

All proteins holding degron of DSGSLAT