DegronMD - Q86YR7(MCF2L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1008F	TCGA-13-0807	OV	TCGA	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1389
p.S1008F	DO28206	OV	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1389
p.R989I	TCGA-17-Z030	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1111
p.S1008C	TCGA-24-2288	OV	TCGA	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1389
p.S1008C	DO29166	OV	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1389
p.R532P	TCGA-60-2698	LUSC	TCGA	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1944
p.R532P	DO26469	LUSC	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1944
p.A538T	TCGA-DU-6392	LGG	TCGA	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation altering degron motif	0.6028
p.A538T	DO22237	LGG	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation altering degron motif	0.6028
p.V548M	TCGA-E2-A14V	BRCA	TCGA	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1667
p.V548M	DO3548	BRCA	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1667
p.T552I	TCGA-EB-A41B	SKCM	TCGA	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0556
p.T552I	DO37611	SKCM	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0556
p.E1011K	TCGA-EE-A2M5	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.0556
p.E1011K	DO222423	MELA	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.0556
p.E1011K	DO37425	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.0556
p.A527T	TCGA-XY-A9T9	TGCT	TCGA	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0556
p.A527T	DO233259	GACA	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0556
p.T992A	TCGA-ZF-AA4W	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1944
p.T992A	DO219089	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1944
p.P536T	DO228971	LICA	ICGC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.3056
p.A998D	DO231212	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.6682
p.S544L	SIDM01175	Other Sarcomas	GDSC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.2778
p.S544L	ACH-002309	Sarcoma	CCLE	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.2778
p.S544L	SW684	soft tissue	COSMIC	VAPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.2778

Kaplan plot for MCF2L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCF2L2

UniProt ID: Q86YR7

Entrez ID: 23101

Protein name: Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCF2L2 in