DegronMD

Uniprot ID: Q86YR7

Source protein: Probable guanine nucleotide exchange factor MCF2L2

Source gene: MCF2L2

Class: LIG_APCC_ABBA_1

Location: 537:542

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5061

ASA_SCORE: 82.85

COIL: 0.8865

CONS_SCORE: 0.3037

DSS_SCORE: 0.6124

HELIX: 0.0452

FCONS_SCORE: 0.9649

RIG_SCORE: 0.5958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R532P	TCGA-60-2698	LUSC	TCGA	VAPHPE	LIG_APCC_ABBA_1	0.1944
p.R532P	DO26469	LUSC	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.1944
p.A538T	TCGA-DU-6392	LGG	TCGA	VAPHPE	LIG_APCC_ABBA_1	0.6028
p.A538T	DO22237	LGG	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.6028
p.V548M	TCGA-E2-A14V	BRCA	TCGA	VAPHPE	LIG_APCC_ABBA_1	0.1667
p.V548M	DO3548	BRCA	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.1667
p.T552I	TCGA-EB-A41B	SKCM	TCGA	VAPHPE	LIG_APCC_ABBA_1	0.0556
p.T552I	DO37611	SKCM	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.0556
p.A527T	TCGA-XY-A9T9	TGCT	TCGA	VAPHPE	LIG_APCC_ABBA_1	0.0556
p.A527T	DO233259	GACA	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.0556
p.P536T	DO228971	LICA	ICGC	VAPHPE	LIG_APCC_ABBA_1	0.3056
p.S544L	SIDM01175	Other Sarcomas	GDSC	VAPHPE	LIG_APCC_ABBA_1	0.2778
p.S544L	ACH-002309	Sarcoma	CCLE	VAPHPE	LIG_APCC_ABBA_1	0.2778
p.S544L	SW684	soft_tissue	COSMIC	VAPHPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YR7	Probable guanine nucleotide exchange factor MCF2L2	LIG_APCC_ABBA_1	537:542	VAPHPE	APC,CDC20,FZR1	0.5061	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons