DegronMD - P55317(FOXA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V29I	TCGA-16-0846	GBM	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.5965
p.V29I	DO13635	GBM	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.5965
p.D14H	TCGA-2G-AAGM	TGCT	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1389
p.E11K	TCGA-55-A4DF	LUAD	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.E11K	TCGA-OL-A66L	BRCA	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.E11K	DO44172	BRCA	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.E11K	DO45318	LUAD	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.N35Y	TCGA-A5-A0G1	UCEC	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1944
p.N35Y	DO42472	UCEC	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1944
p.S28P	TCGA-BS-A0UF	UCEC	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.6752
p.S28P	DO41488	UCEC	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.6752
p.P359S	TCGA-D9-A6EC	SKCM	TCGA	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.2222
p.P359S	TCGA-D9-A6EC	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.P359S	DO50291	SKCM	ICGC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.2222
p.P359S	DO50291	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.E24K	TCGA-EE-A20F	SKCM	TCGA	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.591
p.E24K	DO37961	SKCM	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.591
p.K350N	TCGA-EO-A22X	UCEC	TCGA	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation altering degron motif	0.5806
p.K350N	DO43907	UCEC	ICGC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation altering degron motif	0.5806
p.S361R	TCGA-SB-A6J6	TGCT	TCGA	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.1667
p.S361R	TCGA-SB-A6J6	TGCT	TCGA	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.S362F	DO234249	ESAD	ICGC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.1389
p.S362F	DO234249	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1667
p.N16K	DO228974	LICA	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1944
p.S13R	DO228976	LICA	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1111
p.N35K	DO228985	LICA	ICGC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.1944
p.G344E	DO220891	MELA	ICGC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.1944
p.G344E	DO220891	MELA	ICGC	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.G363A	DO229073	PRAD	ICGC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.1111
p.G363A	DO229073	PRAD	ICGC	PASST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.S40F	SIDM00545	Melanoma	GDSC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.S40F	ACH-000987	Skin Cancer	CCLE	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.S40F	Mewo	skin	COSMIC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.0556
p.A20S	SIDM00466	Ovarian Carcinoma	GDSC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.3056
p.A20S	ACH-000443	Ovarian Cancer	CCLE	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.3056
p.A20S	OVKATE	ovary	COSMIC	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.3056
p.Q23H	SIDM00221	Melanoma	GDSC	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.647
p.Q23H	SIDM01706	Hodgkin's Lymphoma	GDSC	DTQEAYSSVP	CBL_PTK	21:30	Mutation altering degron motif	0.647
p.G339R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.0556
p.G339R	ACH-000784	Esophageal Cancer	CCLE	LKTPASS	DEG_SCF_FBW7_1	349:355	Mutation rewiring degron network	0.0556
p.A20T	ACH-000954	Endometrial/Uterine Cancer	CCLE	DTQEAYSSVP	CBL_PTK	21:30	Mutation rewiring degron network	0.3056

Kaplan plot for FOXA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXA1

UniProt ID: P55317

Entrez ID: 3169

Protein name: Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXA1 in