DegronMD

Uniprot ID: P55317

Source protein: Hepatocyte nuclear factor 3-alpha

Source gene: FOXA1

Class: DEG_SPOP_SBC_1

Location: 352:356

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 78.24

COIL: 0.9492

CONS_SCORE: 0.4131

DSS_SCORE: 0.6776

HELIX: 0.0368

FCONS_SCORE: 1.0852

RIG_SCORE: 0.607

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P359S	TCGA-D9-A6EC	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.25
p.P359S	DO50291	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.25
p.S361R	TCGA-SB-A6J6	TGCT	TCGA	PASST	DEG_SPOP_SBC_1	0.1944
p.S362F	DO234249	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	0.1667
p.G363A	DO229073	PRAD	ICGC	PASST	DEG_SPOP_SBC_1	0.1389
p.G344E	DO220891	MELA	ICGC	PASST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 6 of 6 entries

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Drug responses associated with FOXA1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PASST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6H8Q1	Actin-binding LIM protein 2	DEG_SPOP_SBC_1	287:291	PASST	SPOP	0.9851	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1155:1159	PASST	SPOP	0.7698	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	471:475	PASST	SPOP	0.9789	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	292:296	PASST	SPOP	0.9897	More...
Q9HC52	Chromobox protein homolog 8	DEG_SPOP_SBC_1	132:136	PASST	SPOP	0.981	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	577:581	PASST	SPOP	0.9633	More...
Q9Y6C2	EMILIN-1	DEG_SPOP_SBC_1	139:143	PASST	SPOP	0.9942	More...
Q9BQL6	Fermitin family homolog 1	DEG_SPOP_SBC_1	198:202	PASST	SPOP	0.9238	More...
P55317	Hepatocyte nuclear factor 3-alpha	DEG_SPOP_SBC_1	352:356	PASST	SPOP	0.9993	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	276:280	PASST	SPOP	0.9862	More...
Q6ZNG2	Homeobox protein DBX2	DEG_SPOP_SBC_1	159:163	PASST	SPOP	0.861	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	82:86	PASST	SPOP	0.9981	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	DEG_SPOP_SBC_1	34:38	PASST	SPOP	0.9084	More...
O43278	Kunitz-type protease inhibitor 1	DEG_SPOP_SBC_1	506:510	PASST	SPOP	0.8248	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1159:1163	PASST	SPOP	0.9943	More...
Q9NUT2	Mitochondrial potassium channel ATP-binding subunit	DEG_SPOP_SBC_1	120:124	PASST	SPOP	0.6141	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	85:89	PASST	SPOP	0.795	More...
Q99717	Mothers against decapentaplegic homolog 5	DEG_SPOP_SBC_1	197:201	PASST	SPOP	0.992	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1122:1126	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1568:1572	PASST	SPOP	0.6922	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2205:2209	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2260:2264	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2734:2738	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3125:3129	PASST	SPOP	0.9182	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4208:4212	PASST	SPOP	0.8995	More...

Showing 1 to 25 of 46 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASST

Degron related mutations and impact score

Drug responses associated with FOXA1 mutations

All proteins holding degron of PASST