DegronMD - O43439(CBFA2T2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G563S	TCGA-A6-6648	COAD	TCGA	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.1389
p.G563S	DO10196	COAD	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.1389
p.V575M	TCGA-AU-6004	COAD	TCGA	SADCSVPSP	DEG_COP1_1	570:578	Mutation altering degron motif	0.7208
p.V575M	TCGA-BR-7703	STAD	TCGA	SADCSVPSP	DEG_COP1_1	570:578	Mutation altering degron motif	0.7208
p.V575M	DO7780	COAD	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation altering degron motif	0.7208
p.V575M	DO38232	STAD	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation altering degron motif	0.7208
p.G565D	TCGA-D3-A8GN	SKCM	TCGA	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.1944
p.G565D	DO51240	SKCM	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.1944
p.L107V	TCGA-FI-A2D5	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.0833
p.L107V	DO41331	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.0833
p.P561R	TCGA-IB-7651	PAAD	TCGA	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.0833
p.P561R	DO46657	PAAD	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.0833
p.S96C	TCGA-ZF-A9RC	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.7541
p.S96C	DO219068	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.7541
p.Q106P	DO233751	GACA	ICGC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1111
p.G563V	DO231102	LUSC	ICGC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.1389
p.D581E	SIDM00672	Hepatocellular Carcinoma	GDSC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.25
p.D581E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.25
p.D581E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SADCSVPSP	DEG_COP1_1	570:578	Mutation rewiring degron network	0.25
p.S91G	SIDM00987	Thyroid Gland Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.25
p.S91G	BHT-101	thyroid	COSMIC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.25
p.G103D	ACH-002253	Lymphoma	CCLE	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1944
p.G103D	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1944
p.I570V	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	SADCSVPSP	DEG_COP1_1	570:578	Mutation altering degron motif	0.7076
p.S101G	BHT-101	thyroid	COSMIC	PASST	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.25

Kaplan plot for CBFA2T2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBFA2T2

UniProt ID: O43439

Entrez ID: 9139

Protein name: Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CBFA2T2 in