DegronMD

Uniprot ID: O43439

Source protein: Protein CBFA2T2

Source gene: CBFA2T2

Class: DEG_COP1_1

Location: 570:578

E3 ligase: COP1

DEGRON score: 0.9978

ASA_SCORE: 81.7778

COIL: 0.935

CONS_SCORE: 0.3699

DSS_SCORE: 0.5786

HELIX: 0.0441

FCONS_SCORE: 0.9846

RIG_SCORE: 0.651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G563S	TCGA-A6-6648	COAD	TCGA	SADCSVPSP	DEG_COP1_1	0.1389
p.G563S	DO10196	COAD	ICGC	SADCSVPSP	DEG_COP1_1	0.1389
p.V575M	TCGA-AU-6004	COAD	TCGA	SADCSVPSP	DEG_COP1_1	0.7208
p.V575M	TCGA-BR-7703	STAD	TCGA	SADCSVPSP	DEG_COP1_1	0.7208
p.V575M	DO7780	COAD	ICGC	SADCSVPSP	DEG_COP1_1	0.7208
p.V575M	DO38232	STAD	ICGC	SADCSVPSP	DEG_COP1_1	0.7208
p.G565D	TCGA-D3-A8GN	SKCM	TCGA	SADCSVPSP	DEG_COP1_1	0.1944
p.G565D	DO51240	SKCM	ICGC	SADCSVPSP	DEG_COP1_1	0.1944
p.P561R	TCGA-IB-7651	PAAD	TCGA	SADCSVPSP	DEG_COP1_1	0.0833
p.P561R	DO46657	PAAD	ICGC	SADCSVPSP	DEG_COP1_1	0.0833
p.G563V	DO231102	LUSC	ICGC	SADCSVPSP	DEG_COP1_1	0.1389
p.D581E	SIDM00672	Hepatocellular Carcinoma	GDSC	SADCSVPSP	DEG_COP1_1	0.25
p.D581E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SADCSVPSP	DEG_COP1_1	0.25
p.D581E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SADCSVPSP	DEG_COP1_1	0.25
p.I570V	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	SADCSVPSP	DEG_COP1_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43439	Protein CBFA2T2	DEG_COP1_1	570:578	SADCSVPSP	COP1	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons