DegronMD - Q9BQL6(FERMT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T186I	TCGA-D9-A3Z4	SKCM	TCGA	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.1111
p.T186I	DO37623	SKCM	ICGC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.1111
p.P210S	TCGA-FW-A3R5	SKCM	TCGA	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.0833
p.P210S	TCGA-FW-A3R5	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.P210S	DO37406	SKCM	ICGC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.0833
p.P210S	DO37406	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.S201P	DO233732	GACA	ICGC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation altering degron motif	0.6752
p.S201P	DO233732	GACA	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6752
p.P210T	DO228974	LICA	ICGC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.0833
p.P210T	DO228974	LICA	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.P210T	DO229006	LICA	ICGC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.0833
p.P210T	DO229006	LICA	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.T212K	DO229006	LICA	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.T212M	DO52661	MALY	ICGC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.F206L	SIDM01301	Esophageal Carcinoma	GDSC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.1944
p.F206L	SIDM01301	Esophageal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.M203V	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.2778
p.M203V	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.3056
p.M203V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.2778
p.M203V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.3056
p.A210V	KM12	large intestine	COSMIC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.0833
p.A210V	KM12	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.D189H	CAL-148	breast	COSMIC	INGTPASS	DEG_SCF_FBW7_1	194:201	Mutation rewiring degron network	0.1944
p.D189H	CAL-148	breast	COSMIC	PASST	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833

Kaplan plot for FERMT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FERMT1

UniProt ID: Q9BQL6

Entrez ID: 55612

Protein name: Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FERMT1 in