DegronMD

Uniprot ID: Q9BQL6

Source protein: Fermitin family homolog 1

Source gene: FERMT1

Class: DEG_SCF_FBW7_1

Location: 194:201

E3 ligase: FBXW7

DEGRON score: 0.9025

ASA_SCORE: 64.7375

COIL: 0.8761

CONS_SCORE: 0.3364

DSS_SCORE: 0.4124

HELIX: 0.0582

FCONS_SCORE: 0.9355

RIG_SCORE: 0.6933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T186I	TCGA-D9-A3Z4	SKCM	TCGA	INGTPASS	DEG_SCF_FBW7_1	0.1111
p.T186I	DO37623	SKCM	ICGC	INGTPASS	DEG_SCF_FBW7_1	0.1111
p.P210S	TCGA-FW-A3R5	SKCM	TCGA	INGTPASS	DEG_SCF_FBW7_1	0.0833
p.P210S	DO37406	SKCM	ICGC	INGTPASS	DEG_SCF_FBW7_1	0.0833
p.S201P	DO233732	GACA	ICGC	INGTPASS	DEG_SCF_FBW7_1	0.6752
p.P210T	DO228974	LICA	ICGC	INGTPASS	DEG_SCF_FBW7_1	0.0833
p.P210T	DO229006	LICA	ICGC	INGTPASS	DEG_SCF_FBW7_1	0.0833
p.F206L	SIDM01301	Esophageal Carcinoma	GDSC	INGTPASS	DEG_SCF_FBW7_1	0.1944
p.M203V	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	INGTPASS	DEG_SCF_FBW7_1	0.2778
p.M203V	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	INGTPASS	DEG_SCF_FBW7_1	0.2778
p.A210V	KM12	large_intestine	COSMIC	INGTPASS	DEG_SCF_FBW7_1	0.0833
p.D189H	CAL-148	breast	COSMIC	INGTPASS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQL6	Fermitin family homolog 1	DEG_SCF_FBW7_1	194:201	INGTPASS	FBXW7	0.9025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons