DegronMD

Uniprot ID: O00151

Source protein: PDZ and LIM domain protein 1

Source gene: PDLIM1

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.996

ASA_SCORE: 70.92

COIL: 0.8664

CONS_SCORE: 0.3814

DSS_SCORE: 0.4301

HELIX: 0.0854

FCONS_SCORE: 0.7213

RIG_SCORE: 0.6549

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y144H	TCGA-AA-3672	COAD	TCGA	PASST	DEG_SPOP_SBC_1	0.5278
p.Y144H	DO9010	COAD	ICGC	PASST	DEG_SPOP_SBC_1	0.5278
p.Y144H	ACH-001518	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.5278
p.R122Q	TCGA-AJ-A3EK	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	0.0833
p.R122Q	TCGA-B5-A11E	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	0.0833
p.R122Q	DO41644	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	0.0833
p.R122Q	DO41584	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	0.0833
p.A129T	TCGA-AJ-A3EL	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	0.2778
p.A129T	DO41542	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	0.2778
p.R138M	TCGA-BF-A1Q0	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.25
p.R138M	DO47374	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.25
p.S130W	TCGA-FD-A6TC	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	0.75
p.S130W	DO49755	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	0.75
p.Q143H	SIDM01151	Hepatocellular Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM00235	Kidney Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM00380	Acute Myeloid Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM01770	Gastric Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM00248	Gastric Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM01448	Head and Neck Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SIDM01443	Gastric Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	TE-5	oesophagus	COSMIC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	SNU-182	liver	COSMIC	PASST	DEG_SPOP_SBC_1	0.1111
p.Q143H	RCC10RGB	kidney	COSMIC	PASST	DEG_SPOP_SBC_1	0.1111
p.M125V	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1667
p.M125V	ACH-000706	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.1667
p.M125V	EKVX	lung	COSMIC	PASST	DEG_SPOP_SBC_1	0.1667
p.S130L	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.75
p.S130L	ACH-000605	Esophageal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.75
p.S130L	ACH-001412	Bladder Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.75
p.S130L	TE-6	oesophagus	COSMIC	PASST	DEG_SPOP_SBC_1	0.75
p.A132S	SIDM00394	Cervical Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.6477
p.A132S	SIDM00616	Hepatocellular Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.6477
p.A132S	SIDM00241	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.6477
p.A132S	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.6477
p.A132S	SIDM01498	Acute Myeloid Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	0.6477
p.A137T	SIDM01617	Endometrial Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.2778
p.A137T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00151	PDZ and LIM domain protein 1	DEG_SPOP_SBC_1	131:135	PASST	SPOP	0.996	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	292:296	PASST	SPOP	0.9897	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	284:288	PASST	SPOP	0.9958	More...
O15014	Zinc finger protein 609	DEG_SPOP_SBC_1	422:426	PASST	SPOP	0.9985	More...
O43278	Kunitz-type protease inhibitor 1	DEG_SPOP_SBC_1	506:510	PASST	SPOP	0.8248	More...
O43439	Protein CBFA2T2	DEG_SPOP_SBC_1	94:98	PASST	SPOP	0.9026	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1759:1763	PASST	SPOP	0.8173	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	471:475	PASST	SPOP	0.9789	More...
P55317	Hepatocyte nuclear factor 3-alpha	DEG_SPOP_SBC_1	352:356	PASST	SPOP	0.9993	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	276:280	PASST	SPOP	0.9862	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	938:942	PASST	SPOP	0.9965	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	85:89	PASST	SPOP	0.795	More...
Q5T7P8	Synaptotagmin-6	DEG_SPOP_SBC_1	166:170	PASST	SPOP	0.9966	More...
Q6H8Q1	Actin-binding LIM protein 2	DEG_SPOP_SBC_1	287:291	PASST	SPOP	0.9851	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	220:224	PASST	SPOP	0.996	More...
Q86YR7	Probable guanine nucleotide exchange factor MCF2L2	DEG_SPOP_SBC_1	997:1001	PASST	SPOP	0.999	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	455:459	PASST	SPOP	0.9441	More...
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SPOP_SBC_1	354:358	PASST	SPOP	0.9845	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1155:1159	PASST	SPOP	0.7698	More...
Q8N122	Regulatory-associated protein of mTOR	DEG_SPOP_SBC_1	879:883	PASST	SPOP	0.9966	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	82:86	PASST	SPOP	0.9981	More...
Q8WXH0	Nesprin-2	DEG_SPOP_SBC_1	6481:6485	PASST	SPOP	0.9986	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	654:658	PASST	SPOP	0.7201	More...
Q99717	Mothers against decapentaplegic homolog 5	DEG_SPOP_SBC_1	197:201	PASST	SPOP	0.992	More...
Q9BQL6	Fermitin family homolog 1	DEG_SPOP_SBC_1	198:202	PASST	SPOP	0.9238	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	DEG_SPOP_SBC_1	34:38	PASST	SPOP	0.9084	More...
Q9H9P5	Putative E3 ubiquitin-protein ligase UNKL	DEG_SPOP_SBC_1	409:413	PASST	SPOP	0.8044	More...
Q9HC52	Chromobox protein homolog 8	DEG_SPOP_SBC_1	132:136	PASST	SPOP	0.981	More...
Q9NR12	PDZ and LIM domain protein 7	DEG_SPOP_SBC_1	201:205	PASST	SPOP	0.9989	More...
Q9NUT2	Mitochondrial potassium channel ATP-binding subunit	DEG_SPOP_SBC_1	120:124	PASST	SPOP	0.6141	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	577:581	PASST	SPOP	0.9633	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1122:1126	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1568:1572	PASST	SPOP	0.6922	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2205:2209	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2260:2264	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2734:2738	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3125:3129	PASST	SPOP	0.9182	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4208:4212	PASST	SPOP	0.8995	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1159:1163	PASST	SPOP	0.9943	More...
Q9Y6C2	EMILIN-1	DEG_SPOP_SBC_1	139:143	PASST	SPOP	0.9942	More...
P52746	Zinc finger protein 142	DEG_SPOP_SBC_1	10:14	PASST	SPOP	0.9427	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	13:17	PASST	SPOP	0.9978	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	1735:1739	PASST	SPOP	0.9207	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	36:40	PASST	SPOP	0.9757	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	650:654	PASST	SPOP	0.6155	More...
Q6ZNG2	Homeobox protein DBX2	DEG_SPOP_SBC_1	159:163	PASST	SPOP	0.861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASST

Degron related mutations and impact score

Drug responses associated with PDLIM1 mutations

All proteins holding degron of PASST