DegronMD

Uniprot ID: Q9HC52

Source protein: Chromobox protein homolog 8

Source gene: CBX8

Class: DEG_SPOP_SBC_1

Location: 132:136

E3 ligase: SPOP

DEGRON score: 0.981

ASA_SCORE: 87.46

COIL: 0.9238

CONS_SCORE: 0.6057

DSS_SCORE: 0.7211

HELIX: 0.0486

FCONS_SCORE: 1.0525

RIG_SCORE: 0.5182

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A133V	DO234401	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	0.5825
p.S140N	TCGA-QQ-A8VG	SARC	TCGA	PASST	DEG_SPOP_SBC_1	0.2222
p.S140N	DO220260	SARC	ICGC	PASST	DEG_SPOP_SBC_1	0.2222
p.G128D	SIDM01763	Rhabdomyosarcoma	GDSC	PASST	DEG_SPOP_SBC_1	0.2222
p.M127V	ACH-000961	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.1944
p.R125Q	TCGA-EO-A22U	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	0.1389
p.R125Q	DO43755	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	0.1389
p.R125Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.1389
p.R143L	SIDM00687	Gastric Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1389
p.R143L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1389
p.R143L	KATOIII	stomach	COSMIC	PASST	DEG_SPOP_SBC_1	0.1389
p.R143L	TE-10	oesophagus	COSMIC	PASST	DEG_SPOP_SBC_1	0.1389
p.L124F	TCGA-FW-A3R5	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.1111
p.L124F	DO37406	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.1111
p.A144V	DO23150	LINC	ICGC	PASST	DEG_SPOP_SBC_1	0.1111
p.A144T	DO228338	MALY	ICGC	PASST	DEG_SPOP_SBC_1	0.1111
p.A146V	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 17 of 17 entries

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Drug responses associated with CBX8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PASST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6H8Q1	Actin-binding LIM protein 2	DEG_SPOP_SBC_1	287:291	PASST	SPOP	0.9851	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1155:1159	PASST	SPOP	0.7698	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	471:475	PASST	SPOP	0.9789	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	292:296	PASST	SPOP	0.9897	More...
Q9HC52	Chromobox protein homolog 8	DEG_SPOP_SBC_1	132:136	PASST	SPOP	0.981	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	577:581	PASST	SPOP	0.9633	More...
Q9Y6C2	EMILIN-1	DEG_SPOP_SBC_1	139:143	PASST	SPOP	0.9942	More...
Q9BQL6	Fermitin family homolog 1	DEG_SPOP_SBC_1	198:202	PASST	SPOP	0.9238	More...
P55317	Hepatocyte nuclear factor 3-alpha	DEG_SPOP_SBC_1	352:356	PASST	SPOP	0.9993	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	276:280	PASST	SPOP	0.9862	More...
Q6ZNG2	Homeobox protein DBX2	DEG_SPOP_SBC_1	159:163	PASST	SPOP	0.861	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	82:86	PASST	SPOP	0.9981	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	DEG_SPOP_SBC_1	34:38	PASST	SPOP	0.9084	More...
O43278	Kunitz-type protease inhibitor 1	DEG_SPOP_SBC_1	506:510	PASST	SPOP	0.8248	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1159:1163	PASST	SPOP	0.9943	More...
Q9NUT2	Mitochondrial potassium channel ATP-binding subunit	DEG_SPOP_SBC_1	120:124	PASST	SPOP	0.6141	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	85:89	PASST	SPOP	0.795	More...
Q99717	Mothers against decapentaplegic homolog 5	DEG_SPOP_SBC_1	197:201	PASST	SPOP	0.992	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1122:1126	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1568:1572	PASST	SPOP	0.6922	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2205:2209	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2260:2264	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2734:2738	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3125:3129	PASST	SPOP	0.9182	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4208:4212	PASST	SPOP	0.8995	More...

Showing 1 to 25 of 46 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASST

Degron related mutations and impact score

Drug responses associated with CBX8 mutations

All proteins holding degron of PASST