DegronMD - Q9HC52(CBX8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R125Q	TCGA-EO-A22U	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.R125Q	DO43755	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.R125Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.L124F	TCGA-FW-A3R5	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.L124F	DO37406	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.S140N	TCGA-QQ-A8VG	SARC	TCGA	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.S140N	DO220260	SARC	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.A133V	DO234401	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.5825
p.A144V	DO23150	LINC	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.A144T	DO228338	MALY	ICGC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.A146V	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.R143L	SIDM00687	Gastric Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.R143L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.R143L	KATOIII	stomach	COSMIC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.R143L	TE-10	oesophagus	COSMIC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.G128D	SIDM01763	Rhabdomyosarcoma	GDSC	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.M127V	ACH-000961	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1944

Kaplan plot for CBX8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBX8

UniProt ID: Q9HC52

Entrez ID: 57332

Protein name: Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBX8 in