DegronMD - Q6ZNG2(DBX2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A160E	TCGA-05-4390	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.659
p.A160E	DO23562	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.659
p.R198I	TCGA-19-5956	GBM	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.25
p.R198I	DO13863	GBM	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.25
p.D196Y	TCGA-33-AASB	LUSC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.3056
p.D196Y	DO219125	LUSC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.3056
p.M171I	TCGA-44-6777	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171I	DO23645	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.G154V	TCGA-44-8120	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.G154V	DO45402	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.R184W	TCGA-AH-6903	READ	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R184W	TCGA-FC-A8O0	PRAD	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R184W	DO49765	PRAD	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R184W	DO37299	READ	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R158H	TCGA-AJ-A3EL	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158H	DO41542	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.S149L	TCGA-AX-A2HD	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0556
p.S149L	DO42608	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0556
p.A200T	TCGA-B5-A3FC	UCEC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.A200T	DO41871	UCEC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R158L	TCGA-BA-A6D8	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158L	DO44426	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158C	TCGA-BH-A5J0	BRCA	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158C	DO219608	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158C	DO222576	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158C	DO222804	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158G	TCGA-CR-7402	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.R158G	DO15727	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.A150E	TCGA-CV-7242	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.A150E	DO14974	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.P166L	TCGA-D3-A3C7	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.P166L	DO47569	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.P166S	TCGA-DA-A960	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.P166S	DO219482	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.S194F	TCGA-DD-AACT	LIHC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6871
p.S194F	DO219563	LIHC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6871
p.S194F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6871
p.S194F	ACH-002215	Lymphoma	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6871
p.S194F	BC-3	haematopoietic and lymphoid tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6871
p.R157W	TCGA-E6-A1LZ	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157W	TCGA-FI-A2D5	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157W	DO41331	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157W	DO41398	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157W	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.S155F	TCGA-EE-A29B	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.S155F	TCGA-EE-A2MI	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.S155F	DO37531	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.S155F	DO47255	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.R190K	TCGA-EE-A2MD	SKCM	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6126
p.R190K	DO222434	MELA	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6126
p.R190K	DO37851	SKCM	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6126
p.V192A	TCGA-F5-6814	READ	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6936
p.V192A	DO36556	READ	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.6936
p.A160G	TCGA-G3-A7M7	LIHC	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6429
p.A160G	DO49693	LIHC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6429
p.R167K	TCGA-GD-A76B	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.R167K	DO51886	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.M171V	DO229010	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229013	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229016	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229003	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229005	COCA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229473	LAML	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.M171V	DO229480	LAML	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.E195K	DO233105	GACA	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.7022
p.S161F	DO228929	LICA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7982
p.P166Q	DO229027	LICA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.R158S	DO229026	LICA	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.C156S	DO231127	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.G153S	SIDM00353	Other Sarcomas	GDSC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.G153S	ACH-000505	Sarcoma	CCLE	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.G153S	RKN	ovary	COSMIC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.S179C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.S179C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.S179C	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.S179C	SIDM00122	Breast Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.S179C	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.S179C	SIDM00778	Colorectal Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0556
p.G186D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.25
p.G186D	ACH-000981	Leukemia	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.25
p.G186D	DND-41	haematopoietic and lymphoid tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.25
p.S162F	SIDM01175	Other Sarcomas	GDSC	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7982
p.S162F	SW684	soft tissue	COSMIC	PASST	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.7982
p.R157Q	SIDM00007	Other Solid Cancers	GDSC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157Q	ACH-001550	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.R157Q	MCC13	skin	COSMIC	PASST	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.M204I	SIDM00193	Colorectal Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0833
p.M204I	ACH-000991	Colon/Colorectal Cancer	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0833
p.M204I	SNU-81	large intestine	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.0833
p.R184Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R184Q	ACH-002302	Leukemia	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.R184Q	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.1944
p.V192I	SIDM00878	Breast Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.5965
p.V192I	ACH-000930	Breast Cancer	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.5965
p.V192I	HCC1569	breast	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation altering degron motif	0.5965
p.D196H	SIDM01448	Head and Neck Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	189:195	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBX2

UniProt ID: Q6ZNG2

Entrez ID: 440097

Protein name: Homeobox protein DBX2 (Developing brain homeobox protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBX2 in