DegronMD

Uniprot ID: Q6ZNG2

Source protein: Homeobox protein DBX2

Source gene: DBX2

Class: LIG_APCC_ABBAyCdc20_2

Location: 189:195

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9899

ASA_SCORE: 79.4429

COIL: 0.6939

CONS_SCORE: 0.8119

DSS_SCORE: 0.3797

HELIX: 0.1529

FCONS_SCORE: 1.1475

RIG_SCORE: 0.7982

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R198I	TCGA-19-5956	GBM	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R198I	DO13863	GBM	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.D196Y	TCGA-33-AASB	LUSC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D196Y	DO219125	LUSC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R184W	TCGA-AH-6903	READ	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R184W	TCGA-FC-A8O0	PRAD	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R184W	DO49765	PRAD	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R184W	DO37299	READ	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A200T	TCGA-B5-A3FC	UCEC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A200T	DO41871	UCEC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S194F	TCGA-DD-AACT	LIHC	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S194F	DO219563	LIHC	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S194F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S194F	ACH-002215	Lymphoma	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S194F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.R190K	TCGA-EE-A2MD	SKCM	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R190K	DO222434	MELA	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R190K	DO37851	SKCM	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6126
p.V192A	TCGA-F5-6814	READ	TCGA	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6936
p.V192A	DO36556	READ	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.6936
p.E195K	DO233105	GACA	ICGC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.S179C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S179C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S179C	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S179C	SIDM00122	Breast Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S179C	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S179C	SIDM00778	Colorectal Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G186D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.G186D	ACH-000981	Leukemia	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.G186D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.M204I	SIDM00193	Colorectal Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M204I	ACH-000991	Colon/Colorectal Cancer	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M204I	SNU-81	large_intestine	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R184Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R184Q	ACH-002302	Leukemia	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R184Q	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V192I	SIDM00878	Breast Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V192I	ACH-000930	Breast Cancer	CCLE	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V192I	HCC1569	breast	COSMIC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.D196H	SIDM01448	Head and Neck Carcinoma	GDSC	RRAVFSE	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRAVFSE

Degron related mutations and impact score

Drug responses associated with DBX2 mutations

All proteins holding degron of RRAVFSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNG2	Homeobox protein DBX2	LIG_APCC_ABBAyCdc20_2	189:195	RRAVFSE	APC,CDC20,FZR1	0.9899	More...