DegronMD - O43278(SPINT1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S509T	TCGA-AZ-6598	COAD	TCGA	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation altering degron motif	0.6005
p.S509T	TCGA-AZ-6598	COAD	TCGA	PASST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.6005
p.S509T	DO10276	COAD	ICGC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation altering degron motif	0.6005
p.S509T	DO10276	COAD	ICGC	PASST	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.6005
p.E518K	TCGA-UC-A7PF	CESC	TCGA	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.0833
p.E518K	TCGA-UC-A7PF	CESC	TCGA	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.E518K	DO49987	CESC	ICGC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.0833
p.E518K	DO49987	CESC	ICGC	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.P504S	DO233898	GACA	ICGC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation altering degron motif	0.5641
p.H501Y	SIDM00120	Prostate Carcinoma	GDSC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.3056
p.H501Y	SIDM00120	Prostate Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1944
p.H501Y	ACH-000979	Prostate Cancer	CCLE	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.3056
p.H501Y	ACH-000979	Prostate Cancer	CCLE	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1944
p.H501Y	DU-145	prostate	COSMIC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.3056
p.H501Y	DU-145	prostate	COSMIC	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1944
p.V511I	SIDM00534	Colorectal Carcinoma	GDSC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation rewiring degron network	0.2778
p.V511I	SIDM00534	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.V505I	SNG-M	endometrium	COSMIC	PPPTPASS	DEG_SCF_FBW7_1	502:509	Mutation altering degron motif	0.7076

Kaplan plot for SPINT1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPINT1

UniProt ID: O43278

Entrez ID: 6692

Protein name: Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SPINT1 in