DegronMD

Uniprot ID: O43278

Source protein: Kunitz-type protease inhibitor 1

Source gene: SPINT1

Class: DEG_SCF_FBW7_1

Location: 502:509

E3 ligase: FBXW7

DEGRON score: 0.9613

ASA_SCORE: 82.6875

COIL: 0.9483

CONS_SCORE: 0.5204

DSS_SCORE: 0.6677

HELIX: 0.0245

FCONS_SCORE: 1.1482

RIG_SCORE: 0.5466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S509T	TCGA-AZ-6598	COAD	TCGA	PPPTPASS	DEG_SCF_FBW7_1	0.6005
p.S509T	DO10276	COAD	ICGC	PPPTPASS	DEG_SCF_FBW7_1	0.6005
p.E518K	TCGA-UC-A7PF	CESC	TCGA	PPPTPASS	DEG_SCF_FBW7_1	0.0833
p.E518K	DO49987	CESC	ICGC	PPPTPASS	DEG_SCF_FBW7_1	0.0833
p.P504S	DO233898	GACA	ICGC	PPPTPASS	DEG_SCF_FBW7_1	0.5641
p.H501Y	SIDM00120	Prostate Carcinoma	GDSC	PPPTPASS	DEG_SCF_FBW7_1	0.3056
p.H501Y	ACH-000979	Prostate Cancer	CCLE	PPPTPASS	DEG_SCF_FBW7_1	0.3056
p.H501Y	DU-145	prostate	COSMIC	PPPTPASS	DEG_SCF_FBW7_1	0.3056
p.V511I	SIDM00534	Colorectal Carcinoma	GDSC	PPPTPASS	DEG_SCF_FBW7_1	0.2778
p.V505I	SNG-M	endometrium	COSMIC	PPPTPASS	DEG_SCF_FBW7_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43278	Kunitz-type protease inhibitor 1	DEG_SCF_FBW7_1	502:509	PPPTPASS	FBXW7	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons