DegronMD - Q13233(MAP3K1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T946K	TCGA-63-A5MB	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.T946K	DO52018	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.T947K	TCGA-63-A5MB	LUSC	TCGA	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.T947K	DO52018	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.G996D	TCGA-A5-A0G2	UCEC	TCGA	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.G996D	TCGA-A5-A0G2	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1667
p.G996D	DO41235	UCEC	ICGC	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.G996D	DO41235	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1667
p.G996D	SIDM01608	Endometrial Carcinoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.G996D	SIDM01608	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1667
p.G996D	ACH-000990	Endometrial/Uterine Cancer	CCLE	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.G996D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1667
p.P981A	TCGA-AP-A0LD	UCEC	TCGA	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.2778
p.P981A	TCGA-AP-A0LD	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1944
p.P981A	DO41578	UCEC	ICGC	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.2778
p.P981A	DO41578	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.1944
p.D1000Y	TCGA-AX-A2HC	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.0556
p.D1000Y	DO41572	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.0556
p.T1066A	TCGA-CG-5733	STAD	TCGA	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation altering degron motif	0.7139
p.T1066A	DO38551	STAD	ICGC	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation altering degron motif	0.7139
p.S976F	TCGA-E9-A1N9	BRCA	TCGA	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.S976F	TCGA-E9-A1N9	BRCA	TCGA	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.0556
p.S976F	DO2569	BRCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1389
p.S976F	DO2569	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.0556
p.T990S	DO48448	BLCA	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation altering degron motif	0.6005
p.D132H	DO639	BLCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	132:137	Mutation altering degron motif	0.7688
p.K1061R	DO233109	GACA	ICGC	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation substituting flanking lysine	0.3333
p.G1074E	DO233888	GACA	ICGC	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation rewiring degron network	0.2222
p.P994S	DO11854	GBM	ICGC	LSTPSSS	DEG_SCF_FBW7_1	983:989	Mutation rewiring degron network	0.1944
p.P994S	DO11854	GBM	ICGC	PSSST	DEG_SPOP_SBC_1	986:990	Mutation rewiring degron network	0.2222
p.D1075N	DO11854	GBM	ICGC	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation rewiring degron network	0.1944
p.A81S	DO228978	LICA	ICGC	PASST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.D56Y	DO50894	LICA	ICGC	RRRQLRKVR	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.2778
p.P1076S	DO23376	LINC	ICGC	PTPGNT	DEG_SCF_FBW7_1	1065:1070	Mutation rewiring degron network	0.1667
p.A130E	DO45073	LINC	ICGC	DSGASS	DEG_SCF_TRCP1_1	132:137	Mutation rewiring degron network	0.2778
p.S83A	DO228371	MALY	ICGC	PASST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2778
p.S83A	ACH-000315	Lymphoma	CCLE	PASST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2778
p.H123P	DO218908	SKCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	132:137	Mutation rewiring degron network	0.0833
p.R147G	DO218862	SKCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	132:137	Mutation rewiring degron network	0.0556
p.T942S	DO229121	THCA	ICGC	PSSST	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.6005
p.V936L	SIDM01023	Acute Myeloid Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.V936L	ACH-000006	Leukemia	CCLE	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.V936L	ACH-001129	Leukemia	CCLE	PSSST	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.Q61K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RRRQLRKVR	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.5833
p.Q61K	ACH-000983	Leukemia	CCLE	RRRQLRKVR	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.5833
p.A82V	ACH-001841	Bile Duct Cancer	CCLE	PASST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.25

Kaplan plot for MAP3K1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K1

UniProt ID: Q13233

Entrez ID: 4214

Protein name: Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAP3K1 in