DegronMD

Uniprot ID: Q13233

Source protein: Mitogen-activated protein kinase kinase kinase 1

Source gene: MAP3K1

Class: DEG_SCF_FBW7_1

Location: 1065:1070

E3 ligase: FBXW7

DEGRON score: 0.841

ASA_SCORE: 82.5667

COIL: 0.9465

CONS_SCORE: 0.4444

DSS_SCORE: 0.8718

HELIX: 0.03

FCONS_SCORE: 1.0003

RIG_SCORE: 0.4902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1066A	TCGA-CG-5733	STAD	TCGA	PTPGNT	DEG_SCF_FBW7_1	0.7139
p.T1066A	DO38551	STAD	ICGC	PTPGNT	DEG_SCF_FBW7_1	0.7139
p.K1061R	DO233109	GACA	ICGC	PTPGNT	DEG_SCF_FBW7_1	0.3333
p.G1074E	DO233888	GACA	ICGC	PTPGNT	DEG_SCF_FBW7_1	0.2222
p.D1075N	DO11854	GBM	ICGC	PTPGNT	DEG_SCF_FBW7_1	0.1944
p.P1076S	DO23376	LINC	ICGC	PTPGNT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SCF_FBW7_1	1065:1070	PTPGNT	FBXW7	0.841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons