DegronMD

Uniprot ID: Q13233

Source protein: Mitogen-activated protein kinase kinase kinase 1

Source gene: MAP3K1

Class: DEG_APCC_DBOX_1

Location: 58:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5255

ASA_SCORE: 107.6667

COIL: 0.4152

CONS_SCORE: 0.429

DSS_SCORE: 0.4398

HELIX: 0.4934

FCONS_SCORE: 1.0029

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D56Y	DO50894	LICA	ICGC	RRRQLRKVR	DEG_APCC_DBOX_1	0.2778
p.Q61K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RRRQLRKVR	DEG_APCC_DBOX_1	0.5833
p.Q61K	ACH-000983	Leukemia	CCLE	RRRQLRKVR	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_APCC_DBOX_1	58:66	RRRQLRKVR	APC,CDC20,FZR1	0.5255	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons