DegronMD

Uniprot ID: Q13233

Source protein: Mitogen-activated protein kinase kinase kinase 1

Source gene: MAP3K1

Class: DEG_SCF_FBW7_1

Location: 983:989

E3 ligase: FBXW7

DEGRON score: 0.9873

ASA_SCORE: 91.1

COIL: 0.9686

CONS_SCORE: 0.4367

DSS_SCORE: 0.5692

HELIX: 0.015

FCONS_SCORE: 1.0159

RIG_SCORE: 0.5691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G996D	TCGA-A5-A0G2	UCEC	TCGA	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.G996D	DO41235	UCEC	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.G996D	SIDM01608	Endometrial Carcinoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.G996D	ACH-000990	Endometrial/Uterine Cancer	CCLE	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.P981A	TCGA-AP-A0LD	UCEC	TCGA	LSTPSSS	DEG_SCF_FBW7_1	0.2778
p.P981A	DO41578	UCEC	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.2778
p.S976F	TCGA-E9-A1N9	BRCA	TCGA	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.S976F	DO2569	BRCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.1389
p.P994S	DO11854	GBM	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_FBW7_1	991:997	LSTPSSS	FBXW7	0.9974	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SCF_FBW7_1	983:989	LSTPSSS	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons