DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SCF_FBW7_1

Location: 991:997

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 93.7286

COIL: 0.9416

CONS_SCORE: 0.3624

DSS_SCORE: 0.5005

HELIX: 0.0366

FCONS_SCORE: 1.0098

RIG_SCORE: 0.6426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1002C	TCGA-C8-A27B	BRCA	TCGA	LSTPSSS	DEG_SCF_FBW7_1	0.1944
p.S1002C	DO4623	BRCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.1944
p.S996F	TCGA-FW-A5DX	SKCM	TCGA	LSTPSSS	DEG_SCF_FBW7_1	0.6871
p.S996F	DO47253	SKCM	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.6871
p.S1004F	DO229456	SKCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	0.5833
p.L989P	SIDM00845	Burkitt's Lymphoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	0.2778
p.T993A	SIDM00845	Burkitt's Lymphoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	0.825
p.T993A	SIDM01519	Head and Neck Carcinoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	0.825
p.T993A	ACH-000786	Lymphoma	CCLE	LSTPSSS	DEG_SCF_FBW7_1	0.825
p.T993A	ACH-001067	Brain Cancer	CCLE	LSTPSSS	DEG_SCF_FBW7_1	0.825
p.T993A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPSSS	DEG_SCF_FBW7_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_FBW7_1	991:997	LSTPSSS	FBXW7	0.9974	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SCF_FBW7_1	983:989	LSTPSSS	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons