DegronMD

Uniprot ID: Q13233

Source protein: Mitogen-activated protein kinase kinase kinase 1

Source gene: MAP3K1

Class: DEG_SCF_TRCP1_1

Location: 132:137

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 71.0333

COIL: 0.923

CONS_SCORE: 0.4176

DSS_SCORE: 0.6904

HELIX: 0.0545

FCONS_SCORE: 1.0508

RIG_SCORE: 0.5348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D132H	DO639	BLCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	0.7688
p.A130E	DO45073	LINC	ICGC	DSGASS	DEG_SCF_TRCP1_1	0.2778
p.H123P	DO218908	SKCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	0.0833
p.R147G	DO218862	SKCA	ICGC	DSGASS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SCF_TRCP1_1	132:137	DSGASS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons