DegronMD

Uniprot ID: P55317

Source protein: Hepatocyte nuclear factor 3-alpha

Source gene: FOXA1

Class: DEG_SCF_FBW7_1

Location: 349:355

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 85.1857

COIL: 0.9396

CONS_SCORE: 0.3786

DSS_SCORE: 0.672

HELIX: 0.0389

FCONS_SCORE: 0.9818

RIG_SCORE: 0.6259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P359S	TCGA-D9-A6EC	SKCM	TCGA	LKTPASS	DEG_SCF_FBW7_1	0.2222
p.P359S	DO50291	SKCM	ICGC	LKTPASS	DEG_SCF_FBW7_1	0.2222
p.K350N	TCGA-EO-A22X	UCEC	TCGA	LKTPASS	DEG_SCF_FBW7_1	0.5806
p.K350N	DO43907	UCEC	ICGC	LKTPASS	DEG_SCF_FBW7_1	0.5806
p.S361R	TCGA-SB-A6J6	TGCT	TCGA	LKTPASS	DEG_SCF_FBW7_1	0.1667
p.S362F	DO234249	ESAD	ICGC	LKTPASS	DEG_SCF_FBW7_1	0.1389
p.G344E	DO220891	MELA	ICGC	LKTPASS	DEG_SCF_FBW7_1	0.1944
p.G363A	DO229073	PRAD	ICGC	LKTPASS	DEG_SCF_FBW7_1	0.1111
p.G339R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LKTPASS	DEG_SCF_FBW7_1	0.0556
p.G339R	ACH-000784	Esophageal Cancer	CCLE	LKTPASS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55317	Hepatocyte nuclear factor 3-alpha	DEG_SCF_FBW7_1	349:355	LKTPASS	FBXW7	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons