DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DTQEAYSSVP
Uniprot ID:
P55317
Source protein:
Hepatocyte nuclear factor 3-alpha
Source gene:
FOXA1
Class:
CBL_PTK
Location:
21:30
E3 ligase:
CBL
DEGRON score:
0.9659
ASA_SCORE:
71.34
COIL:
0.7379
CONS_SCORE:
0.3391
DSS_SCORE:
0.3497
HELIX:
0.1589
FCONS_SCORE:
0.872
RIG_SCORE:
0.7747
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V29I
TCGA-16-0846
GBM
TCGA
DTQEAYSSVP
CBL_PTK
0.5965
p.V29I
DO13635
GBM
ICGC
DTQEAYSSVP
CBL_PTK
0.5965
p.D14H
TCGA-2G-AAGM
TGCT
TCGA
DTQEAYSSVP
CBL_PTK
0.1389
p.E11K
TCGA-55-A4DF
LUAD
TCGA
DTQEAYSSVP
CBL_PTK
0.0556
p.E11K
TCGA-OL-A66L
BRCA
TCGA
DTQEAYSSVP
CBL_PTK
0.0556
p.E11K
DO44172
BRCA
ICGC
DTQEAYSSVP
CBL_PTK
0.0556
p.E11K
DO45318
LUAD
ICGC
DTQEAYSSVP
CBL_PTK
0.0556
p.N35Y
TCGA-A5-A0G1
UCEC
TCGA
DTQEAYSSVP
CBL_PTK
0.1944
p.N35Y
DO42472
UCEC
ICGC
DTQEAYSSVP
CBL_PTK
0.1944
p.S28P
TCGA-BS-A0UF
UCEC
TCGA
DTQEAYSSVP
CBL_PTK
0.6752
p.S28P
DO41488
UCEC
ICGC
DTQEAYSSVP
CBL_PTK
0.6752
p.E24K
TCGA-EE-A20F
SKCM
TCGA
DTQEAYSSVP
CBL_PTK
0.591
p.E24K
DO37961
SKCM
ICGC
DTQEAYSSVP
CBL_PTK
0.591
p.N16K
DO228974
LICA
ICGC
DTQEAYSSVP
CBL_PTK
0.1944
p.S13R
DO228976
LICA
ICGC
DTQEAYSSVP
CBL_PTK
0.1111
p.N35K
DO228985
LICA
ICGC
DTQEAYSSVP
CBL_PTK
0.1944
p.S40F
SIDM00545
Melanoma
GDSC
DTQEAYSSVP
CBL_PTK
0.0556
p.S40F
ACH-000987
Skin Cancer
CCLE
DTQEAYSSVP
CBL_PTK
0.0556
p.S40F
Mewo
skin
COSMIC
DTQEAYSSVP
CBL_PTK
0.0556
p.A20S
SIDM00466
Ovarian Carcinoma
GDSC
DTQEAYSSVP
CBL_PTK
0.3056
p.A20S
ACH-000443
Ovarian Cancer
CCLE
DTQEAYSSVP
CBL_PTK
0.3056
p.A20S
OVKATE
ovary
COSMIC
DTQEAYSSVP
CBL_PTK
0.3056
p.Q23H
SIDM00221
Melanoma
GDSC
DTQEAYSSVP
CBL_PTK
0.647
p.Q23H
SIDM01706
Hodgkin's Lymphoma
GDSC
DTQEAYSSVP
CBL_PTK
0.647
p.A20T
ACH-000954
Endometrial/Uterine Cancer
CCLE
DTQEAYSSVP
CBL_PTK
0.3056
Drug responses associated with FOXA1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTQEAYSSVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P55317
Hepatocyte nuclear factor 3-alpha
CBL_PTK
21:30
DTQEAYSSVP
CBL
0.9659
More...