DegronMD

Uniprot ID: Q9NYV4

Source protein: Cyclin-dependent kinase 12

Source gene: CDK12

Class: DEG_APCC_DBOX_1

Location: 662:670

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7022

ASA_SCORE: 88.6444

COIL: 0.6328

CONS_SCORE: 0.3792

DSS_SCORE: 0.7489

HELIX: 0.3464

FCONS_SCORE: 1.0501

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P653L	TCGA-29-1711	OV	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.0833
p.P653L	DO30630	OV	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.0833
p.G677C	TCGA-35-4122	LUAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.G677C	DO23782	LUAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.G677D	TCGA-35-4122	LUAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.G677D	TCGA-BS-A0UJ	UCEC	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.G677D	DO23782	LUAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.G677D	DO42745	UCEC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.1389
p.P653H	TCGA-AP-A059	UCEC	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.0833
p.P653H	DO41361	UCEC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.0833
p.R663C	TCGA-CM-4743	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.8301
p.R663C	TCGA-CM-4746	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	0.8301
p.R663C	DO8103	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.8301
p.R663C	DO7882	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.8301
p.V654L	DO229052	LICA	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.1111
p.R663L	DO224563	LUSC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYV4	Cyclin-dependent kinase 12	DEG_APCC_DBOX_1	662:670	TRHLLTDLP	APC,CDC20,FZR1	0.7022	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons